Rv3684

Tuberculist information
Gene nameRv3684
Protein functionProbable lyase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4125.44
Molecular mass(da)37623.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 346
	  		  	1    LIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNG   60
			  	61   WINENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNS  120
			  	121  SQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAESIYVQMREEKHPTPEWIVVGA  180
			  	181  GTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVE  240
			  	241  PSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGS  300
			  	301  VVTLLADSGDRYADTYFSDEWVSAQGLDPAGPAAALVEFERSCRWT

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 10 to 307  |  Coverage: 85% PALP Range: 7 to 326  |  Coverage: 92% 1 Range: 1 to 342  |  Coverage: 98% 1 Range: 71 to 323  |  Coverage: 72% 2
Number of amino acids : 346
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PALPPF0029110-307
Mtb Structural Proteome models
Model Number1
Model nameRv3684
Template1JBQ    APDBCREDO
Template coverage82_395
Template Identity(%)26.4
Model coverage(%)92.2
Normalized DOPE score-0.139

Structure Models from Chopin
Model Number1
Profilec.79.1.1
Click for model details
zscore34.2
Residue begin1
Residue end342
Model Number2
Profile3.40.50.1100
Click for model details
zscore16.66
Residue begin71
Residue end323
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3684Gene nameConfidence Score
Rv2335cysE0.92
Rv2335cysE0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
O-acetylserinePubChem0.938147.129
L-selenocysteinePubChem0.9168.053
acetatePubChem0.959.044
half-cystinePubChem0.9121.158
O-acetyl-L-serinePubChem0.9147.129