Rv3025c

Tuberculist information
Gene nameiscS
Protein functionCysteine desulfurase IscS (NIFS protein homolog) (nitrogenase metalloclusters biosynthesis protein NIFS)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3383.89
Molecular mass(da)40947.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 393
	  		  	1    MAYLDHAATTPMHPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPS   60
			  	61   EVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTW  120
			  	121  LPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPMHSDA  180
			  	181  IQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRRDVTCVPLMHGGGQERDIRSGT  240
			  	241  PDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLAEIDDVCLNGADDPMRLAGNA  300
			  	301  HFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGH  360
			  	361  TSVEADVDAALEVLPGAVARARRAALAAAGASR

Known structures in the PDB
PDB ID4ISY
Total residue count1616
Number of chains4
MethodX-RAY
Resolution2.59
1 40 79 118 157 196 235 274 313 352 391 Range: 2 to 370  |  Coverage: 93% Aminotran_5 Range: 2 to 389  |  Coverage: 98% 1 Range: 1 to 393  |  Coverage: 99% 1
Number of amino acids : 393
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_5PF002662-370
Mtb Structural Proteome models
Model Number1
Model nameRv3025c
Template1P3W    BPDBCREDO
Template coverage5_388
Template Identity(%)40.2
Model coverage(%)98.5
Normalized DOPE score-0.362

Structure Models from Chopin
Model Number1
Profilec.67.1.3
Click for model details
zscore27.02
Residue begin1
Residue end393
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3025cGene nameConfidence Score
Rv3024ctrmU0.998
Rv3116moeB20.993
Rv3116moeB20.993
Rv3116moeB20.993
Rv2204cRv2204c0.979
Rv1465Rv14650.97
Rv1287Rv12870.96
Rv3206cmoeB10.956
Rv3206cmoeB10.956
Rv3206cmoeB10.956
Rv2335cysE0.943
Rv0350dnaK0.943
Rv2335cysE0.943
Rv1463Rv14630.919
Rv0422cthiD0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
half-cystinePubChem0.981121.158
pyridoxal phosphatePubChem0.924247.142
4Fe-4SPubChem0.84888.9179
Fe(III)PubChem0.80955.845