Tuberculist information
Gene namethiD
Protein functionProbable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)507.758
Molecular mass(da)27510.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 265
	  		  	1    MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVV   60
			  	61   AGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAP  120
			  	121  SALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGHL  180
			  	181  RSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRW  240
			  	241  VTECLRAAYPLGRGHGPVSPLFRLS
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Phos_pyr_kinPF0854313-259
Mtb Structural Proteome models
Model Number1
Model nameRv0422c
Template1UB0    APDBCREDO
Template coverage2_257
Template Identity(%)46.7
Model coverage(%)97.0
Normalized DOPE score-0.544

Structure Models from Chopin
Model Number1
Profilec.72.1.2 - 3.40.1190.20
Click for model details
zscore32.57
Residue begin1
Residue end265
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0422cGene nameConfidence Score
Rv0414cthiE0.999
Rv0423cthiC0.999
Rv0423cthiC0.999
Rv0417thiG0.987
Rv2977cthiL0.986
Rv2977cthiL0.986
Rv2682cdxs10.964
Rv2682cdxs10.964
Rv2682cdxs10.964
Rv2150cftsZ0.93
Rv2150cftsZ0.93
Rv3116moeB20.914
Rv3116moeB20.914
Rv3116moeB20.914
Rv3455ctruA0.91
Rv3025ciscS0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
4-amino-5-hydroxymethyl-2-methylpyrimidinePubChem0.99139.155
hydroxymethylpyrimidine phosphatePubChem0.963219.135
thiamine monophosphatePubChem0.951345.334
pyrophosphatePubChem0.939177.975
adenosine diphosphatePubChem0.931427.201
HMP-PPPubChem0.915299.115
S-adenosyl-methioninePubChem0.9398.437
phosphoribosylaminoimidazolePubChem0.9294.178
deuteriumPubChem0.92.01588
5-aminoimidazole ribonucleotidePubChem0.9295.186
S-adenosyl-L-methioninePubChem0.9399.445
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
4-methyl-5-(beta-hydroxyethyl)thiazole phosphatePubChem0.9223.187
5'-deoxyadenosinePubChem0.9251.242
L-methioninePubChem0.9149.211
H(+)PubChem0.92.01588
sulfatePubChem0.78596.0626
hydron sulfatePubChem0.785196.157
glycerolPubChem0.72392.0938
phosphatePubChem0.71996.9872
thiaminePubChem0.708265.355
selenomethioninePubChem0.707196.106
dioxanePubChem0.788.1051