Rv0423c

Tuberculist information
Gene namethiC
Protein functionProbable thiamine biosynthesis protein ThiC
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)508.582
Molecular mass(da)59897.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 547
	  		  	1    MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDLYDTSGPYTDT   60
			  	61   DTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAAREDMSAELVRDEVARGRAV  120
			  	121  IPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTG  180
			  	181  KNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVH  240
			  	241  AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYDVTFSLG  300
			  	301  DGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGHIPMHKIVENVRLEEEL  360
			  	361  CEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPDRKDVKDG  420
			  	421  VIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAE  480
			  	481  PAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNR  540
			  	541  VYLPITQ

Known structures in the PDB
No Known structures
1 55 109 163 217 271 325 379 433 487 541 Range: 12 to 83  |  Coverage: 12% ThiC-associated Range: 82 to 505  |  Coverage: 77% ThiC
Number of amino acids : 547
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ThiC-associatedPF1366712-83
ThiCPF0196482-505
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0423cGene nameConfidence Score
Rv0422cthiD0.999
Rv0414cthiE0.999
Rv0417thiG0.998
Rv3116moeB20.919
Rv3116moeB20.919
Rv3116moeB20.919
Rv0415thiO0.918
Rv1589bioB0.914
Rv1589bioB0.914
Rv3206cmoeB10.907
Rv3206cmoeB10.907
Rv3206cmoeB10.907
Rv3276cpurK0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
4-amino-5-hydroxymethyl-2-methylpyrimidinePubChem0.993139.155
hydroxymethylpyrimidine phosphatePubChem0.99219.135
5-aminoimidazole ribonucleotidePubChem0.967295.186
HMP-PPPubChem0.948299.115
5'-deoxyadenosinePubChem0.943251.242
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
deuteriumPubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
S-adenosyl-methioninePubChem0.9398.437
phosphoribosylaminoimidazolePubChem0.9294.178
L-methioninePubChem0.9149.211
S-adenosyl-L-methioninePubChem0.9399.445
H(+)PubChem0.92.01588
thiaminePubChem0.783265.355
thiamine monophosphatePubChem0.764345.334
thiamine pyrophosphatePubChem0.76425.314
thiazolePubChem0.74185.1276
4-methyl-5-(beta-hydroxyethyl)thiazolePubChem0.736143.207
pyrophosphatePubChem0.718177.975
IRNPubChem0.704279.164
hydron sulfatePubChem0.704196.157
zincPubChem0.70465.409
sulfatePubChem0.70496.0626
SeMetPubChem0.704196.106
selenomethioninePubChem0.704196.106