Rv1589

Tuberculist information
Gene namebioB
Protein functionProbable biotin synthetase BioB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1790.28
Molecular mass(da)37517.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 349
	  		  	1    VTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAVLQLPDDRLEELLALA   60
			  	61   HEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFASPVRSAWLDIPSLVEAAKQTA  120
			  	121  KSGATEFCIVAAVRGPDERLMAQVAAGIEAIRNEVEINIACSLGMLTAEQVDQLAARGVH  180
			  	181  RYNHNLETARSFFANVVTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETLQQRAEFAAE  240
			  	241  LAELGPDEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFRLALPRTMLRFAGGREITLG  300
			  	301  DLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQMPLKALNASL

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 80 to 241  |  Coverage: 46% Radical_SAM Range: 250 to 342  |  Coverage: 26% BATS Range: 36 to 344  |  Coverage: 88% 1 Range: 34 to 345  |  Coverage: 89% 1
Number of amino acids : 349
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Radical_SAMPF0405580-241
BATSPF06968250-342
Mtb Structural Proteome models
Model Number1
Model nameRv1589
Template1R30    APDBCREDO
Template coverage6_314
Template Identity(%)32.7
Model coverage(%)88.3
Normalized DOPE score-0.349

Structure Models from Chopin
Model Number1
Profilec.1.28.1 - 3.20.20.70
Click for model details
zscore51.66
Residue begin34
Residue end345
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1589Gene nameConfidence Score
Rv1568bioA0.999
Rv1570bioD0.999
Rv3279cbirA0.994
Rv3279cbirA0.994
Rv1569bioF10.984
Rv2733cRv2733c0.968
Rv2733cRv2733c0.968
Rv2733cRv2733c0.968
Rv1590Rv15900.935
Rv2678chemE0.932
Rv3329Rv33290.925
Rv0869cmoaA20.919
Rv0869cmoaA20.919
Rv0869cmoaA20.919
Rv0423cthiC0.914
Rv0423cthiC0.914
Rv3601cpanD0.911
Rv2218lipA0.91
Rv0417thiG0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
dethiobiotinPubChem0.992214.262
S-adenosyl-L-methioninePubChem0.991399.445
7,8-diaminopelargonic acidPubChem0.975188.267
5'-deoxyadenosinePubChem0.961251.242
L-methioninePubChem0.943149.211
d-biotinPubChem0.938244.311
S-adenosyl-methioninePubChem0.93398.437
DTBPubChem0.905214.262
H(+)PubChem0.92.01588
carbon dioxidePubChem0.944.0095
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
phosphatePubChem0.996.9872
7,8-diaminononanoic acidPubChem0.9188.267
adenosine triphosphatePubChem0.9507.181
7-keto-8-aminopelargonic acidPubChem0.751187.236
sulphurPubChem0.73534.0809