Rv2218

Tuberculist information
Gene namelipA
Protein functionProbable lipoate biosynthesis protein A LipA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2485.27
Molecular mass(da)34718.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 311
	  		  	1    MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGC   60
			  	61   PNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPRRVADSVRTMGLRYATV  120
			  	121  TGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHN  180
			  	181  VETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAG  240
			  	241  CDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRLYE  300
			  	301  QARNSRALASR

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 76 to 236  |  Coverage: 51% Radical_SAM Range: 25 to 309  |  Coverage: 91% 1 Range: 19 to 311  |  Coverage: 93% 1
Number of amino acids : 311
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Radical_SAMPF0405576-236
Mtb Structural Proteome models
Model Number1
Model nameRv2218
Template1R30    APDBCREDO
Template coverage4_275
Template Identity(%)19.9
Model coverage(%)91.3
Normalized DOPE score0.261

Structure Models from Chopin
Model Number1
Profilec.1.28.1 - 3.20.20.70
Click for model details
zscore9.33
Residue begin19
Residue end311
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2218Gene nameConfidence Score
Rv2217lipB0.999
Rv2215dlaT0.964
Rv2215dlaT0.964
Rv2215dlaT0.964
Rv2495cbkdC0.917
Rv2495cbkdC0.917
Rv2495cbkdC0.917
Rv1589bioB0.91
Rv1589bioB0.91
Rv2733cRv2733c0.909
Rv2733cRv2733c0.909
Rv2733cRv2733c0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
lipoic acidPubChem0.745206.326