Rv2733c

Tuberculist information
Gene nameRv2733c
Protein functionConserved hypothetical alanine, arginine-rich protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)3044.99
Molecular mass(da)55085.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 512
	  		  	1    MVAHDAAAGVTGEGAGPPVRRAPARTYQVRTYGCQMNVHDSERLAGLLEAAGYRRATDGS   60
			  	61   EADVVVFNTCAVRENADNRLYGNLSHLAPRKRANPDMQIAVGGCLAQKDRDAVLRRAPWV  120
			  	121  DVVFGTHNIGSLPTLLERARHNKVAQVEIAEALQQFPSSLPSSRESAYAAWVSISVGCNN  180
			  	181  SCTFCIVPSLRGREVDRSPADILAEVRSLVNDGVLEVTLLGQNVNAYGVSFADPALPRNR  240
			  	241  GAFAELLRACGDIDGLERVRFTSPHPAEFTDDVIEAMAQTRNVCPALHMPLQSGSDRILR  300
			  	301  AMRRSYRAERYLGIIERVRAAIPHAAITTDLIVGFPGETEEDFAATLDVVRRARFAAAFT  360
			  	361  FQYSKRPGTPAAQLDGQLPKAVVQERYERLIALQEQISLEANRALVGQAVEVLVATGEGR  420
			  	421  KDTVTARMSGRARDGRLVHFTAGQPRVRPGDVITTKVTEAAPHHLIADAGVLTHRRTRAG  480
			  	481  DAHTAGQPGRAVGLGMPGVGLPVSAAKPGGCR

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 26 to 125  |  Coverage: 19% UPF0004 Range: 172 to 350  |  Coverage: 34% Radical_SAM Range: 403 to 465  |  Coverage: 12% TRAM Range: 128 to 475  |  Coverage: 67% 1 Range: 180 to 394  |  Coverage: 41% 1 Range: 130 to 448  |  Coverage: 62% 2
Number of amino acids : 512
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
UPF0004PF0091926-125
Radical_SAMPF04055172-350
TRAMPF01938403-465
Mtb Structural Proteome models
Model Number1
Model nameRv2733c
Template1R30    APDBCREDO
Template coverage8_314
Template Identity(%)15.0
Model coverage(%)67.8
Normalized DOPE score0.486

Structure Models from Chopin
Model Number1
Profile3.80.30.20
Click for model details
zscore34.42
Residue begin180
Residue end394
Model Number2
Profilec.1.28.1 - 3.20.20.70
Click for model details
zscore8.34
Residue begin130
Residue end448
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2733cGene nameConfidence Score
Rv1589bioB0.968
Rv1589bioB0.968
Rv2727cmiaA0.965
Rv2732cRv2732c0.964
Rv2388chemN0.938
Rv2388chemN0.938
Rv2218lipA0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions