Rv2727c

Tuberculist information
Gene namemiaA
Protein functionProbable tRNA delta(2)-isopentenylpyrophosphate transferase MiaA (IPP transferase) (isopentenyl-diphosphate:tRNA isopentenyltransferase) (iptase) (IPPT)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3039.82
Molecular mass(da)34414.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 314
	  		  	1    VRPLAIIGPTGAGKSQLALDVAARLGARVSVEIVNADAMQLYRGMDIGTAKLPVSERRGI   60
			  	61   PHHQLDVLDVTETATVARYQRAAAADIEAIAARGAVPVVVGGSMLYVQSLLDDWSFPATD  120
			  	121  PSVRARWERRLAEVGVDRLHAELARRDPAAAAAILPTDARRTVRALEVVELTGQPFAASA  180
			  	181  PRIGAPRWDTVIVGLDCQTTILDERLARRTDLMFDQGLVEEVRTLLRNGLREGVTASRAL  240
			  	241  GYAQVIAALDAGAGADMMRAAREQTYLGTRRYVRRQRSWFRRDHRVHWLDAGVASSPDRA  300
			  	301  RLVDDAVRLWRHVT

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 39 to 292  |  Coverage: 80% IPPT Range: 1 to 240  |  Coverage: 76% 1 Range: 1 to 314  |  Coverage: 99% 1 Range: 199 to 285  |  Coverage: 27% 2 Range: 1 to 187  |  Coverage: 59% 3
Number of amino acids : 314
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IPPTPF0171539-292
Mtb Structural Proteome models
Model Number1
Model nameRv2727c
Template1SXJ    BPDBCREDO
Template coverage42_266
Template Identity(%)19.1
Model coverage(%)76.1
Normalized DOPE score1.187

Structure Models from Chopin
Model Number1
Profile1.10.287.890, 3.40.50.300
Click for model details
zscore36.58
Residue begin1
Residue end314
Model Number2
Profile1.10.287.890
Click for model details
zscore27.72
Residue begin199
Residue end285
Model Number3
Profilec.37.1.2 - 3.40.50.300
Click for model details
zscore5.54
Residue begin1
Residue end187
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2727cGene nameConfidence Score
Rv2725chflX0.992
Rv2725chflX0.992
Rv2906ctrmD0.983
Rv2733cRv2733c0.965
Rv2733cRv2733c0.965
Rv2733cRv2733c0.965
Rv2217lipB0.956
Rv1406fmt0.936
Rv1406fmt0.936
Rv2726cdapF0.926
Rv3024ctrmU0.917
Rv2748cftsK0.916
Rv2748cftsK0.916
Rv2748cftsK0.916
Rv2534cefp0.915
Rv2534cefp0.915
Rv2440cobg0.915
Rv2440cobg0.915
Rv2440cobg0.915
Rv2534cefp0.915
Rv3420crimI0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
SeMetPubChem0.796196.106
magnesiumPubChem0.79624.305
selenomethioninePubChem0.796196.106
pyrophosphatePubChem0.783177.975
dimethylallyl-S-thiolodiphosphatePubChem0.749264.174
hydron; phosphonato phosphatePubChem0.741175.959
dimethylallyl diphosphatePubChem0.74246.092
UNNPubChem0.7375.414