Rv2748c

Tuberculist information
Gene nameftsK
Protein functionPossible cell division transmembrane protein FtsK
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3059.85
Molecular mass(da)94406.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 883
	  		  	1    MLGPPGTPRVGRRDAARSLVTLLRRPWQRGEQIAVTSVADGVDGVIATRLAVMSSKTVAR   60
			  	61   SGTRTSRSKATSRGASRSARSAVPRKRSRPVKGVGRPSRRHHRSLLVSTGLACGRAMRAV  120
			  	121  WMMAAKGTGGAARSIGRARDIEPGHRRDGIALVLLGLAVVVAASSWFDAARPLGAWVDAL  180
			  	181  LRTFIGSAVVMLPLVAAAVAVVLMRTSPNPDSRPRLILGASLIGLSFLGLCHLWAGSPEA  240
			  	241  PESRLRAAGFIGFAIGGPLSDGLTAWIAAPLLFIGALFGLLLLAGITIREVPDAMRAMFG  300
			  	301  TRLLPREYADDFEDFADFDGDDADTVEVARQDFSDGYYDEVPLCSDDGPPAWPSAEVPQD  360
			  	361  DTATIPEASAGRGSGRRGRRKDTQVLDRIVEGPYTLPSLDLLISGDPPKKRSAANTHMAG  420
			  	421  AIGEVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQRNIAYAVATESVRMLA  480
			  	481  PIPGKSAVGIEVPNTDREMVRLADVLTARETRRDHHPLVIGLGKDIEGDFISANLAKMPH  540
			  	541  LLVAGSTGSGKSSFVNSMLVSLLTRATPEEVRMILIDPKMVELTPYEGIPHLITPIITQP  600
			  	601  KKAAAALAWLVDEMEQRYQDMQASRVRHIDDFNDKVRSGAITAPLGSQREYRPYPYVVAI  660
			  	661  VDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFA  720
			  	721  TSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPLRLQGAYVSDEEIHAVVTACKEQAE  780
			  	781  PEYTEGVTTAKPTAERTDVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAG  840
			  	841  RLMDLMETRGIVGPSEGSKAREVLVKPDELAGTLAAIRGDGGE

Known structures in the PDB
No Known structures
1 89 177 265 353 441 529 617 705 793 881 Range: 117 to 244  |  Coverage: 14% DUF4117 Range: 501 to 702  |  Coverage: 22% FtsK_SpoIIIE Range: 803 to 868  |  Coverage: 7% Ftsk_gamma Range: 511 to 739  |  Coverage: 25% 1 Range: 801 to 870  |  Coverage: 7% 1 Range: 396 to 683  |  Coverage: 32% 2
Number of amino acids : 883
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF4117PF13491117-244
FtsK_SpoIIIEPF01580501-702
Ftsk_gammaPF09397803-868
Mtb Structural Proteome models
Model Number1
Model nameRv2748c
Template1B0U    APDBCREDO
Template coverage5_249
Template Identity(%)13.5
Model coverage(%)25.8
Normalized DOPE score0.207

Structure Models from Chopin
Model Number1
Profilea.4.5.67
Click for model details
zscore19.53
Residue begin801
Residue end870
Model Number2
Profilec.37.1.11 - 3.40.50.300
Click for model details
zscore9.22
Residue begin396
Residue end683
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2748cGene nameConfidence Score
Rv2150cftsZ0.991
Rv2150cftsZ0.991
Rv0017crodA0.967
Rv2154cftsW0.965
Rv2136cRv2136c0.926
Rv2158cmurE0.916
Rv2158cmurE0.916
Rv2158cmurE0.916
Rv2727cmiaA0.916
Rv3646ctopA0.907
Rv3646ctopA0.907
Rv2921cftsY0.907
Rv2921cftsY0.907
Rv3646ctopA0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions