Rv2921c

Tuberculist information
Gene nameftsY
Protein functionProbable cell division protein FtsY (SRP receptor) (signal recognition particle receptor)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3232.87
Molecular mass(da)43999.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 422
	  		  	1    VWEGLWIATAVIAALVVIAALTLGLVLYRRRRISLSPRPERGVVDRSGGYTASSGITFSQ   60
			  	61   TPTTQPAERIDTSGLPAVGDDATVPRDAPKRTIADVHLPEFEPEPQAPEVPEADAIAPPE  120
			  	121  GRLERLRGRLARSQNALGRGLLGLIGGGDLDEDSWQDVEDTLLVADLGPAATASVVSQLR  180
			  	181  SRLASGNVRTEADARAVLRDVLINELQPGMDRSIRALPHAGHPSVLLVVGVNGTGKTTTV  240
			  	241  GKLARVLVADGRRVVLGAADTFRAAAADQLQTWAARVGAAVVRGPEGADPASVAFDAVDK  300
			  	301  GIAAGADVVLIDTAGRLHTKVGLMDELDKVKRVVTRRASVDEVLLVLDATIGQNGLAQAR  360
			  	361  VFAEVVDISGAVLTKLDGTAKGGIVFRVQQELGVPVKLVGLGEGPDDLAPFEPAAFVDAL  420
			  	421  LG

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 126 to 206  |  Coverage: 18% SRP54_N Range: 223 to 422  |  Coverage: 47% SRP54 Range: 121 to 421  |  Coverage: 71% 1 Range: 123 to 422  |  Coverage: 70% 1 Range: 126 to 206  |  Coverage: 18% 2 Range: 223 to 421  |  Coverage: 46% 3
Number of amino acids : 422
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SRP54_NPF02881126-206
SRP54PF00448223-422
Mtb Structural Proteome models
Model Number1
Model nameRv2921c
Template1VMA    APDBCREDO
Template coverage2_292
Template Identity(%)48.1
Model coverage(%)71.1
Normalized DOPE score-1.162

Structure Models from Chopin
Model Number1
Profilea.24.13.1, c.37.1.10
Click for model details
zscore50.15
Residue begin123
Residue end422
Model Number2
Profile1.20.120.140
Click for model details
zscore15.46
Residue begin126
Residue end206
Model Number3
Profilec.37.1.10 - 3.40.50.300
Click for model details
zscore11.46
Residue begin223
Residue end421
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2921cGene nameConfidence Score
Rv0732secY0.984
Rv2916cffh0.983
Rv2916cffh0.983
Rv2916cffh0.983
Rv2922csmc0.964
Rv2922csmc0.964
Rv2587csecD0.959
Rv2587csecD0.959
Rv2586csecF0.957
Rv2586csecF0.957
Rv2925crnc0.956
Rv2925crnc0.956
Rv2150cftsZ0.946
Rv2150cftsZ0.946
Rv2462ctig0.943
Rv2462ctig0.943
Rv2462ctig0.943
Rv2614cthrS0.93
Rv2614cthrS0.93
Rv2614cthrS0.93
Rv3610cftsH0.925
Rv3610cftsH0.925
Rv3610cftsH0.925
Rv2909crpsP0.923
Rv2906ctrmD0.922
Rv2093ctatC0.914
Rv2904crplS0.91
Rv0640rplK0.909
Rv0640rplK0.909
Rv2748cftsK0.907
Rv2748cftsK0.907
Rv2748cftsK0.907
Rv2889ctsf0.903
Rv2889ctsf0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.7424.305