Rv2586c

Tuberculist information
Gene namesecF
Protein functionProbable protein-export membrane protein SecF
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2912.68
Molecular mass(da)47013.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 442
	  		  	1    MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEV   60
			  	61   VGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALG  120
			  	121  SEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFGPKGTDGQPSKQAISDSAVS  180
			  	181  ETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEV  240
			  	241  TPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTS  300
			  	301  LIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVR  360
			  	361  NHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGITQASSQSAPRAAQGSSKPAP  420
			  	421  GARPVRPVGTRRPTGKRNAGRR

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 81 to 108  |  Coverage: 6% Sec_GG Range: 160 to 355  |  Coverage: 44% SecD_SecF Range: 95 to 360  |  Coverage: 59% 1 Range: 136 to 373  |  Coverage: 53% 1
Number of amino acids : 442
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sec_GGPF0754981-108
SecD_SecFPF02355160-355
Mtb Structural Proteome models
Model Number1
Model nameRv2586c
Template1T9X    APDBCREDO
Template coverage247_518
Template Identity(%)14.4
Model coverage(%)60.0
Normalized DOPE score1.257

Structure Models from Chopin
Model Number1
Profile1.20.1640.10
Click for model details
zscore8.57
Residue begin136
Residue end373
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2586cGene nameConfidence Score
Rv2587csecD0.999
Rv2587csecD0.999
Rv0732secY0.997
Rv1821secA20.984
Rv1821secA20.984
Rv1821secA20.984
Rv0638secE10.982
Rv3240csecA10.98
Rv3240csecA10.98
Rv3240csecA10.98
Rv2903clepB0.964
Rv2903clepB0.964
Rv2916cffh0.962
Rv2916cffh0.962
Rv2916cffh0.962
Rv2921cftsY0.957
Rv2921cftsY0.957
Rv1440secG0.942
Rv2588cyajC0.929
Rv2225panB0.928
Rv3846sodA0.927
Rv3846sodA0.927
Rv2093ctatC0.909
Rv2555calaS0.907
Rv2555calaS0.907
Rv2555calaS0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions