Rv1821

Tuberculist information
Gene namesecA2
Protein functionPossible preprotein translocase ATPase SecA2
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2066.46
Molecular mass(da)88919.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 808
	  		  	1    VNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSR   60
			  	61   SLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRP  120
			  	121  FDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWM  180
			  	181  GPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP  240
			  	241  DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRN  300
			  	301  VHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLIN  360
			  	361  ASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAA  420
			  	421  GEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR  480
			  	481  DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGG  540
			  	541  SDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANL  600
			  	601  DHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERR  660
			  	661  NTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR  720
			  	721  ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARP  780
			  	781  TSTWTYMVNDNPLSDDTLSALSLPGVFR

Known structures in the PDB
No Known structures
1 81 161 241 321 401 481 561 641 721 801 Range: 46 to 425  |  Coverage: 46% SecA_DEAD Range: 268 to 381  |  Coverage: 13% SecA_PP_bind Range: 614 to 677  |  Coverage: 7% SecA_SW Range: 666 to 765  |  Coverage: 12% SecA_SW Range: 19 to 748  |  Coverage: 90% 1 Range: 266 to 392  |  Coverage: 15% 1
Number of amino acids : 808
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SecA_DEADPF0751746-425
SecA_PP_bindPF01043268-381
SecA_SWPF07516614-677
SecA_SWPF07516666-765
Mtb Structural Proteome models
Model Number1
Model nameRv1821
Template1NKT    APDBCREDO
Template coverage-6_818
Template Identity(%)40.3
Model coverage(%)90.2
Normalized DOPE score-0.017

Structure Models from Chopin
Model Number1
Profilea.162.1.1
Click for model details
zscore32.96
Residue begin266
Residue end392
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1821Gene nameConfidence Score
Rv0732secY0.997
Rv2586csecF0.984
Rv2586csecF0.984
Rv2587csecD0.983
Rv2587csecD0.983
Rv3846sodA0.979
Rv3846sodA0.979
Rv0638secE10.937
Rv3240csecA10.93
Rv3240csecA10.93
Rv3240csecA10.93
Rv1440secG0.919
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions