Rv2587c

Tuberculist information
Gene namesecD
Protein functionProbable protein-export membrane protein SecD
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2914.01
Molecular mass(da)60235.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 573
	  		  	1    VASSSAPVHPARYLSVFLVMLIGIYLLVFFTGDKHTAPKLGIDLQGGTRVTLTARTPDGS   60
			  	61   APSREALAQAQQIISARVNGLGVSGSEVVVDGDNLVITVPGNDGSEARNLGQTARLYIRP  120
			  	121  VLNSMPAQPAAEEPQPAPSAEPQPPGQPAAPPPAQSGAPASPQPGAQPRPYPQDPAPSPN  180
			  	181  PTSPASPPPAPPAEAPATDPRKDLAERIAQEKKLRQSTNQYMQMVALQFQATRCESDDIL  240
			  	241  AGNDDPKLPLVTCSTDHKTAYLLAPSIISGDQIQNATSGMDQRGIGYVVDLQFKGPAANI  300
			  	301  WADYTAAHIGTQTAFTLDSQVVSAPQIQEAIPGGRTQISGGDPPFTAATARQLANVLKYG  360
			  	361  SLPLSFEPSEAQTVSATLGLSSLRAGMIAGAIGLLLVLVYSLLYYRVLGLLTALSLVASG  420
			  	421  SMVFAILVLLGRYINYTLDLAGIAGLIIGIGTTADSFVVFFERIKDEIREGRSFRSAVPR  480
			  	481  GWARARKTIVSGNAVTFLAAAVLYFLAIGQVKGFAFTLGLTTILDLVVVFLVTWPLVYLA  540
			  	541  SKSSLLAKPAYNGLGAVQQVARERRAMARTGRG

Known structures in the PDB
No Known structures
1 58 115 172 229 286 343 400 457 514 571 Range: 27 to 60  |  Coverage: 5% Sec_GG Range: 358 to 543  |  Coverage: 32% SecD_SecF Range: 340 to 565  |  Coverage: 39% 1
Number of amino acids : 573
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sec_GGPF0754927-60
SecD_SecFPF02355358-543
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profile1.20.1640.10
Click for model details
zscore9.01
Residue begin340
Residue end565
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2587cGene nameConfidence Score
Rv2586csecF0.999
Rv2586csecF0.999
Rv0732secY0.996
Rv1821secA20.983
Rv1821secA20.983
Rv1821secA20.983
Rv0638secE10.982
Rv3240csecA10.98
Rv3240csecA10.98
Rv3240csecA10.98
Rv2916cffh0.962
Rv2916cffh0.962
Rv2916cffh0.962
Rv2921cftsY0.959
Rv2921cftsY0.959
Rv2588cyajC0.949
Rv1440secG0.94
Rv2903clepB0.928
Rv2903clepB0.928
Rv2093ctatC0.926
Rv3846sodA0.92
Rv3846sodA0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Beta-cateninc1ccc(cc1)Oc2ccccc2C(=O)[O-]
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@@]4(C)[C@H]3CC(=O)C5=C4C(=O)OC5C
Beta-cateninC/1(N(C(/C=2/C(=N1)/N(/N=C\N2)C)=O)C)=O
Beta-cateninc1c(c(ccc1)C(=O)N\N=C\c1oc(cc1)C)Oc1ccccc1
Beta-cateninCc1oc(C=NNC(=O)c2ccccc2Oc3ccccc3)cc1
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]4CC=C([C@@H]5[C@H](O)C[C@]45[C@H](C[C@H]23)OC(=O)C)C(=O)C
Beta-cateninc12c3c4c(cc(c5c4c(c\4c3c(c(c1)O)C(\C(=C4\C[C@H](C)O)\OC)=O)/C(=C(\C5=O)/OC)/C[C@H](C)O)O)OCO2
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@@]4(C)[C@H]3CC=C([C@@H]4C(=O)O)C(=O)C
Beta-cateninCc1c(Br)cc2C(=C3C=C(Br)C(=O)C(=C3Oc2c1Br)Br)c4ccccc4C(=O)O
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@]4(C)[C@@H](O)C(=CC[C@@H]34)C(=O)C
Beta-cateninc1ccc(c(c1)C2=C3C=CC(=O)C=C3Oc4c2ccc(c4)[O-])C(=O)[O-]
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@]4(C)C5=C(C(=O)C=C34)C(C)(O)OC5=O
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]4CC=C([C@@H]5[C@@H](O)C[C@]45[C@H](C[C@H]23)OC(=O)C)C(=O)C
Beta-cateninc1(cccc2c1C(C(c1c2cc(c(c1O)C)C(CCC)=O)=O)=O)O
Beta-cateninCCC(O)CC(=O)O[C@@H]1C[C@H]2[C@]3(C)CC[C@H]4[C@@](C)(CC)CCC[C@]4(C)[C@H]3C[C@H](OC(=O)C)[C@]2(C)[C@H]([C@@H]1C(=O)C)C(=O)O
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3F)ccc2NC1=O
BRD4Cc1sc2c(C(=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n23)c4ccc(Cl)cc4)c1C
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3n4c(N)nnc14
BRD4Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4n12
BRD4CCC1=NCc2nnc(c3ccncc3)n2c4ccc(Cl)cc14
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccccc3Cl
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3N=C1NNC(=O)C
BRD4Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCc3ccccc3
BRD4CCOc1cccc(c1)c2c(C)onc2C
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3NC1=S
BRD4Cc1onc(C)c1c2ccc(OCCN3CCNCC3)c(c2)S(=O)(=O)NC4CCCC4
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3n4c(C)nnc14
BRD4CCC1=NCC(=S)Nc2ccc(Cl)cc12
BRD4Cc1onc(C)c1c2ccc(OCCCN3CCOCC3)c(c2)S(=O)(=O)NC4CCCC4
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCCO
BRD4COCCNS(=O)(=O)c1cc(ccc1C)c2c(C)onc2C
BRD4Cc1onc(C)c1c2ccc(O)c(c2)S(=O)(=O)NC3CCCC3
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(C)O
BRD4COc1ccc(NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C)cc1
BRD4COc1ccc(cc1S(=O)(=O)Nc2ccccc2)c3c(C)onc3C
BRD4CN1Cc2cc(ccc2NC1=O)S(=O)(=O)N3CCCC3
BRD4CN1Cc2cc(ccc2NC1=O)S(=O)(=O)Nc3ccccc3
BRD4CCNS(=O)(=O)c1cc(ccc1C)c2c(C)onc2C
BRD4CN1Cc2cc(Br)ccc2NC1=O
BRD4CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3ccc(OC)cc3n4c(C)nnc14
BRD4COc1ccccc1S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC(C)(C)C
BRD4COc1ccc(cc1S(=O)(=O)NCc2ccccc2)c3c(C)onc3C
BRD4CCOC(=O)c1ncn2c1[C@@H]3CCCN3C(=O)c4cc(OC)ccc24
BRD4COc1ccc(cc1)S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4COc1ccc(cc1S(=O)(=O)NC2CCCC2)c3c(C)onc3C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(C)cc3)ccc2NC1=O
BRD4CN1CCCC1=O
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3C)ccc2NC1=O
BRD4CN1Cc2cc(ccc2NC1=O)c3c(C)onc3C
BRD4CN1Cc2ccccc2NC1=O
BRD4Clc1ccc2N3C=NNC3=CN=C(c4ccccc4)c2c1
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCC3
BRD4Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4n12
BRD4Cc1nnc2C(NC(=O)OCc3ccccc3)N=C(c4ccccc4)c5ccccc5n12
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3cccc(Cl)c3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCOCC3
BRD4CCC1=NCc2nnc(C)n2c3ccc(Cl)cc13
BRD4CC(O)c1cccc(c1)c2c(C)onc2C
BRD4CCC1=NCc2nnc(c3ccccc3)n2c4ccc(Cl)cc14
BRD4Cc1onc(C)c1c2ccccc2
BRD4CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3cc(OC)ccc3n4c(C)nnc14
BRD4COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(=O)N)C(=O)CN(CCCCN)C(=O)CN(CCc1ccc(O)cc1)C(=O)CNCC(C)C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccc(Cl)cc3
BRD4CCC1=NCc2nnc(c3cccc(OC)c3)n2c4ccc(Cl)cc14
BRD4CC(=O)c1cccc(c1)c2c(C)onc2C
BRD4CC1CCc2ccccc2N1C(=O)C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3C(F)(F)F)ccc2NC1=O
BRD4CCC1=NCC(=O)Nc2ccc(Cl)cc12
BRD4CC(=O)Nc1ccc(O)cc1
BRD4CC(C)CN(CC(=O)N(CCCCN)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(=O)N)Cc1occc1)C(=O)CNCCCN2CCCC2=O
BRD4COc1ccc(cc1S(=O)(=O)NC2CCCNC2)c3c(C)onc3C
BRD4Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c4ccccc4)c5ccccc5n12
BRD4COc1ccc(cc1S(=O)(=O)NC2CCNCC2)c3c(C)onc3C
BRD4COc1cccc(c1)S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4CC(=O)c1cc(c2ccccn2)c3ccccn13
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCNCC3
BRD4CCOC(=O)c1cc(OCC)cc(c1)c2c(C)onc2C
BRD4CN1Cc2cc(ccc2N(C)C1=O)S(=O)(=O)N3CCOCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCNCC3
BRD4COc1ccccc1NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C
BRD4COc1ccc(cc1S(=O)(=O)N2CCNCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2cccc(c2)S(=O)(=O)NC3CC3
BRD4CCN(C1CCCC1)S(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCCc3ccccc3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCc3ccccc3
BRD4COc1ccc(cc1S(=O)(=O)Nc2ccccc2Cl)c3c(C)onc3C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(F)cc3Cl)ccc2NC1=O
BRD4COc1ccc(NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C)cc1
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2NC1=O
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(=O)O
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CC3
BRD4COc1cccc(NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C)c1
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3N4C(=O)NN=C14
BRD4COc1ccc(cc1S(=O)(=O)NC2CC2)c3c(C)onc3C
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(=O)C
BRD4Cc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4n12
BRD4COc1ccc(cc1S(=O)(=O)N2CCOCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCCCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCNC3
BRD4COc1ccccc1NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C
BRD4CCNS(=O)(=O)c1ccc2NC(=O)N(C)Cc2c1
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCCC3
BRD4CCC1=NCc2nnc(CC)n2c3ccc(Cl)cc13
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3)ccc2NC1=O
BRD4COc1ccc(cc1S(=O)(=O)N(C)C2CCCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccccc3
BRD4COc1cccc(NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C)c1
ZipAc1(c(cc2c(c1)N1\C(=C(/N2)\C)\C(=C(/C1=O)\CC(=O)O)\C)Cl)Cl
ZipAc1ccc2c(c1)c1c3n2C(C[C@@]2([C@@]3(N(CC1)CCC2)[H])[H])=O
ZipAc1(nc(oc1c1ccccc1)CCC(=O)O)c1ccccc1
ZipAc1cc(cc(n1)N1CCN(CC1)CCN)c1ccnc(n1)Nc1ccc(c(c1)Cl)C
ZipAc1ccc2c(c1)n(c1c2cnn2c1nnc2)C
ZipACc1ccc(Nc2nccc(n2)c3ccnc(c3)N4CCN(CCN)CC4)cc1Cl
ZipAc1ccc2c(c1)c1c(n2CCCN)c2c(CC1)cccc2
ZipAc1ccc2c(c1)cc(n2CCCN)C1CCCN(C1)C(c1ccc(cc1)c1ccccc1)=O
ZipAc1ccc2c(c1)cc1n2c2[n+](c3c1cccc3)CCC2
ZipAc1ccc2c(c1)c1c(n2CCCNS(=O)(=O)C(C)C)C2N(CC1=O)CCCC2
ZipAc1ccc2c(c1)c1c([nH]2)C2N(CC1=O)CCCC2
ZipAc1c(cc2c(c1)c(c1c(n2)ccc(c1)OC)NC(CCCO)C)Cl
ZipAc1ccc2c(c1)n(c1c2CCc2c1cccc2)CCCN
ZipAc1ccc2c(c1)cc(n2CCC(=O)NCCN1CCCC1)c1cccc(c1)Cl
ZipAc1ccc2c(c1)c(c([nH]2)c1ccccc1)c1cccc(c1)c1cccc(c1)C(=O)O
ZipAc1cc(cc(c1)N(C(C)=O)C)c1nnc2n1nc(cc2)c1ccccc1
ZipAc1ccc2c(c1)c1c(C2=O)nc2c(n1)cccn2
ZipAn1nnn(c1CC)C/C(=N/Nc1ccccn1)/C
ZipACN(C(=O)C)c1cccc(c1)c2nnc3ccc(nn23)c4ccccc4
ZipAc1ccc2c(c1)c(n[nH]2)c1ccncc1
ZipAc1ccc2c(c1)cc(nc2N)c1ncccc1
ZipAc1ccc2c(c1)[nH]c1c2[C@H](CO[C@]1(CC)CC(O)=O)C(=O)c1ccccc1
ZipAc1cc(nc(n1)c1ccncc1)c1sccc1
STITCH interactions  
No high confidence interactions