Rv2903c

Tuberculist information
Gene namelepB
Protein functionProbable signal peptidase I LepB (SPASE I) (leader peptidase I).
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3212.97
Molecular mass(da)31848.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 294
	  		  	1    VTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPA   60
			  	61   KRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYR  120
			  	121  FGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIGFVPPDENDLVKRVIAVG  180
			  	181  GQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNR  240
			  	241  THSADSRAHCPLLCTDDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 91 to 158  |  Coverage: 22% Peptidase_S24 Range: 125 to 276  |  Coverage: 51% Peptidase_S26 Range: 83 to 286  |  Coverage: 69% 1 Range: 2 to 294  |  Coverage: 99% 1
Number of amino acids : 294
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_S24PF0071791-158
Peptidase_S26PF10502125-276
Mtb Structural Proteome models
Model Number1
Model nameRv2903c
Template1B12    APDBCREDO
Template coverage77_323
Template Identity(%)30.4
Model coverage(%)69.0
Normalized DOPE score0.425

Structure Models from Chopin
Model Number1
Profileb.87.1.2
Click for model details
zscore19.17
Residue begin2
Residue end294
Binding pockets
STRING
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Protein interacting with Rv2903cGene nameConfidence Score
Rv2586csecF0.964
Rv2586csecF0.964
Rv2902crnhB0.954
Rv2404clepA0.935
Rv2404clepA0.935
Rv2404clepA0.935
Rv2404clepA0.935
Rv2925crnc0.93
Rv2925crnc0.93
Rv2587csecD0.928
Rv2587csecD0.928
Rv2904crplS0.923
Rv1539lspA0.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions