Rv1539

Tuberculist information
Gene namelspA
Protein functionProbable lipoprotein signal peptidase LspA
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1742.24
Molecular mass(da)21312.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 202
	  		  	1    VPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPP   60
			  	61   GQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGL  120
			  	121  GMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADPSVVGGAILLVILSIFGF  180
			  	181  DFDTVGRRHADGDTVGRRKADG

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 36 to 184  |  Coverage: 73% Peptidase_A8
Number of amino acids : 202
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_A8PF0125236-184
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
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Protein interacting with Rv1539Gene nameConfidence Score
Rv1540Rv15400.997
Rv1540Rv15400.997
Rv1614lgt0.979
Rv2786cribF0.95
Rv2786cribF0.95
Rv1536ileS0.923
Rv1536ileS0.923
Rv2903clepB0.916
Rv2903clepB0.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
globomycinPubChem0.922655.823
Triton X-114PubChem0.714294.429