Rv2786c

Tuberculist information
Gene nameribF
Protein functionProbable bifunctional FAD synthetase/riboflavin biosynthesis protein RibF: riboflavin kinase (flavokinase) + FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)(FAD diphosphorylase) (flavin adenine dinucleotide synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3093.91
Molecular mass(da)36058.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 331
	  		  	1    VRRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELIAHAVKAGRARGVPAVLMT   60
			  	61   FDPHPMEVVYPGSHPAQLTTLTRRAELVQDLGIEVFLVMPFTTDFMKLTPDRFIHELLVE  120
			  	121  HLHVVEVVVGENFTFGKKAAGNVDTLRRAGERFGFAVESMSLVSEHHSNETVTFSSTYIR  180
			  	181  SCVDAGDMVAAMEALGRPHRVEGVVVRGEGRGAELGFPTANVAPPMYSAIPADGVYAAWF  240
			  	241  TVLGHGPVTGTVVPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTTADLYGQHVALDFVGR  300
			  	301  IRGQKKFESVRQLVAAMGADTERARDLLSTG

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 17 to 177  |  Coverage: 48% FAD_syn Range: 194 to 329  |  Coverage: 40% Flavokinase Range: 25 to 328  |  Coverage: 91% 1 Range: 25 to 331  |  Coverage: 92% 1 Range: 208 to 331  |  Coverage: 37% 2 Range: 17 to 177  |  Coverage: 48% 3 Range: 18 to 315  |  Coverage: 89% 4
Number of amino acids : 331
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_synPF0657417-177
FlavokinasePF01687194-329
Mtb Structural Proteome models
Model Number1
Model nameRv2786c
Template1MRZ    APDBCREDO
Template coverage2_281
Template Identity(%)32.4
Model coverage(%)91.5
Normalized DOPE score0.25

Structure Models from Chopin
Model Number1
Profileb.43.5.1, c.26.1.3 - 2.40.30.30, 3.40.50.620
Click for model details
zscore38.85
Residue begin25
Residue end331
Model Number2
Profile2.40.30.30
Click for model details
zscore24.81
Residue begin208
Residue end331
Model Number3
Profilec.26.1.3 - 3.40.50.620
Click for model details
zscore8.91
Residue begin17
Residue end177
Model Number4
Profilec.26.1.3 - 3.40.50.620
Click for model details
zscore8.74
Residue begin18
Residue end315
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2786cGene nameConfidence Score
Rv2785crpsO0.994
Rv1416ribH0.99
Rv2793ctruB0.965
Rv2793ctruB0.965
Rv1391dfp0.961
Rv1391dfp0.961
Rv1409ribG0.955
Rv1409ribG0.955
Rv1539lspA0.95
Rv2965ckdtB0.946
Rv1536ileS0.94
Rv1536ileS0.94
Rv1412ribC0.934
Rv2763cdfrA0.932
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv1406fmt0.902
Rv1406fmt0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
riboflavinPubChem0.99376.364
flavin mononucleotidePubChem0.983456.344
adenosine diphosphatePubChem0.968427.201
flavin adenine dinucleotidePubChem0.945785.55
pyrophosphatePubChem0.901177.975
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedionePubChem0.9276.247
NSC112207PubChem0.9785.55
6,7-dimethyl-8-ribityllumazinePubChem0.9326.305
FAD semiquinonePubChem0.9376.364
5-amino-2,6-dioxo-4-ribitylaminopyrimidinePubChem0.9276.247
6,7-dimethyl-8-(2,3,4,5-tetrahydroxypentyl)pteridine-2,4-dionePubChem0.9326.305
adenosine triphosphatePubChem0.9507.181
SeMetPubChem0.773196.106
selenomethioninePubChem0.773196.106
flavinsPubChem0.765242.233
magnesiumPubChem0.70524.305