Rv2783c

Tuberculist information
Gene namegpsI
Protein functionBifunctional protein polyribonucleotide nucleotidyltransferase GpsI: guanosine pentaphosphate synthetase + polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (pnpase)
Functional category(tuberculist)information pathways
Gene location(kb)3090.34
Molecular mass(da)79734.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 752
	  		  	1    MSAAEIDEGVFETTATIDNGSFGTRTIRFETGRLALQAAGAVVAYLDDDNMLLSATTASK   60
			  	61   NPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLR  120
			  	121  NEIQIVVTILSLDPGDLYDVLAINAASASTQLGGLPFSGPIGGVRVALIDGTWVGFPTVD  180
			  	181  QIERAVFDMVVAGRIVEGDVAIMMVEAEATENVVELVEGGAQAPTESVVAAGLEAAKPFI  240
			  	241  AALCTAQQELADAAGKSGKPTVDFPVFPDYGEDVYYSVSSVATDELAAALTIGGKAERDQ  300
			  	301  RIDEIKTQVVQRLADTYEGREKEVGAALRALTKKLVRQRILTDHFRIDGRGITDIRALSA  360
			  	361  EVAVVPRAHGSALFERGETQILGVTTLDMIKMAQQIDSLGPETSKRYMHHYNFPPFSTGE  420
			  	421  TGRVGSPKRREIGHGALAERALVPVLPSVEEFPYAIRQVSEALGSNGSTSMGSVCASTLA  480
			  	481  LLNAGVPLKAPVAGIAMGLVSDDIQVEGAVDGVVERRFVTLTDILGAEDAFGDMDFKVAG  540
			  	541  TKDFVTALQLDTKLDGIPSQVLAGALEQAKDARLTILEVMAEAIDRPDEMSPYAPRVTTI  600
			  	601  KVPVDKIGEVIGPKGKVINAITEETGAQISIEDDGTVFVGATDGPSAQAAIDKINAIANP  660
			  	661  QLPTVGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVE  720
			  	721  IADIDKRGKISLILVADEDSTAAATDAATVTS

Known structures in the PDB
No Known structures
1 76 151 226 301 376 451 526 601 676 751 Range: 23 to 156  |  Coverage: 17% RNase_PH Range: 159 to 237  |  Coverage: 10% RNase_PH_C Range: 273 to 351  |  Coverage: 10% PNPase Range: 354 to 487  |  Coverage: 17% RNase_PH Range: 490 to 572  |  Coverage: 10% RNase_PH_C Range: 597 to 654  |  Coverage: 7% KH_1 Range: 662 to 734  |  Coverage: 9% S1 Range: 13 to 729  |  Coverage: 95% 1 Range: 23 to 156  |  Coverage: 17% 1 Range: 354 to 487  |  Coverage: 17% 2 Range: 1 to 79  |  Coverage: 10% 3 Range: 273 to 351  |  Coverage: 10% 4 Range: 597 to 654  |  Coverage: 7% 5 Range: 1 to 79  |  Coverage: 10% 6 Range: 159 to 237  |  Coverage: 10% 7 Range: 490 to 568  |  Coverage: 10% 8
Number of amino acids : 752
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RNase_PHPF0113823-156
RNase_PH_CPF03725159-237
PNPasePF03726273-351
RNase_PHPF01138354-487
RNase_PH_CPF03725490-572
KH_1PF00013597-654
S1PF00575662-734
Mtb Structural Proteome models
Model Number1
Model nameRv2783c
Template1E3P    APDBCREDO
Template coverage8_717
Template Identity(%)74.1
Model coverage(%)95.2
Normalized DOPE score0.022

Structure Models from Chopin
Model Number1
Profile3.30.230.70
Click for model details
zscore22.96
Residue begin23
Residue end156
Model Number2
Profile3.30.230.70
Click for model details
zscore22.96
Residue begin354
Residue end487
Model Number3
Profilea.4.9.1, d.101.1.1, d.14.1.4, d.52.3.1 - 1.10.10.400, 3.30.230.70
Click for model details
zscore13.58
Residue begin1
Residue end79
Model Number4
Profilea.4.9.1 - 1.10.10.400
Click for model details
zscore12.03
Residue begin273
Residue end351
Model Number5
Profiled.51.1.1 - 3.30.1370.10
Click for model details
zscore11.6
Residue begin597
Residue end654
Model Number6
Profile3.30.230.70
Click for model details
zscore10.23
Residue begin1
Residue end79
Model Number7
Profile3.30.230.70
Click for model details
zscore10.23
Residue begin159
Residue end237
Model Number8
Profile3.30.230.70
Click for model details
zscore10.23
Residue begin490
Residue end568
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2783cGene nameConfidence Score
Rv3457crpoA0.995
Rv3457crpoA0.995
Rv2839cinfB0.995
Rv2785crpsO0.995
Rv2839cinfB0.995
Rv2839cinfB0.995
Rv2839cinfB0.995
Rv3457crpoA0.995
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv2883cpyrH0.987
Rv2445cndkA0.987
Rv1617pykA0.986
Rv1617pykA0.986
Rv1712cmk0.985
Rv0733adk0.984
Rv2793ctruB0.983
Rv2793ctruB0.983
Rv2782cpepR0.981
Rv2782cpepR0.981
Rv1713engA0.975
Rv1713engA0.975
Rv2841cnusA0.972
Rv2841cnusA0.972
Rv1437pgk0.962
Rv0684fusA10.957
Rv1023eno0.957
Rv0684fusA10.957
Rv1023eno0.957
Rv0684fusA10.957
Rv0684fusA10.957
Rv0684fusA10.957
Rv2906ctrmD0.955
Rv0702rplD0.95
Rv2838crbfA0.946
Rv1630rpsA0.945
Rv0716rplE0.942
Rv0716rplE0.942
Rv0041leuS0.941
Rv0041leuS0.941
Rv0041leuS0.941
Rv1438tpi0.94
Rv0639nusG0.939
Rv0639nusG0.939
Rv1389gmk0.939
Rv2889ctsf0.937
Rv2889ctsf0.937
Rv2462ctig0.936
Rv2462ctig0.936
Rv2462ctig0.936
Rv0732secY0.935
Rv3051cnrdE0.934
Rv3051cnrdE0.934
Rv3051cnrdE0.934
Rv0707rpsC0.933
Rv3456crplQ0.933
Rv0707rpsC0.933
Rv2752cRv2752c0.931
Rv2752cRv2752c0.931
Rv3396cguaA0.93
Rv3396cguaA0.93
Rv3396cguaA0.93
Rv0704rplB0.927
Rv0704rplB0.927
Rv2580chisS0.926
Rv2580chisS0.926
Rv0056rplI0.925
Rv0056rplI0.925
Rv0701rplC0.923
Rv0685tuf0.923
Rv0685tuf0.923
Rv0685tuf0.923
Rv0721rpsE0.921
Rv0721rpsE0.921
Rv0053rpsF0.92
Rv1080cgreA0.915
Rv1080cgreA0.915
Rv0570nrdZ0.914
Rv0570nrdZ0.914
Rv0570nrdZ0.914
Rv2909crpsP0.912
Rv3458crpsD0.912
Rv2786cribF0.912
Rv3458crpsD0.912
Rv2786cribF0.912
Rv0350dnaK0.911
Rv2904crplS0.91
Rv1390rpoZ0.907
Rv1408rpe0.907
Rv3010cpfkA0.906
Rv1341Rv13410.904
Rv0641rplA0.904
Rv3048cnrdF20.903
Rv3411cguaB20.903
Rv3411cguaB20.903
Rv1981cnrdF10.903
Rv0723rplO0.903
Rv3460crpsM0.902
Rv0682rpsL0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine diphosphatePubChem0.916443.201
adenosine diphosphatePubChem0.904427.201
cytidine diphosphatePubChem0.9403.176
uridine diphosphatePubChem0.9404.161
magnesiumPubChem0.8124.305
manganesePubChem0.79254.938
guanylatePubChem0.706363.221
calciumPubChem0.70340.078
ethylene glycol; hydronPubChem0.70363.0758
selenomethioninePubChem0.703196.106
SeMetPubChem0.703196.106
polyethylene glycolPubChem0.70362.0678