Rv1712

Tuberculist information
Gene namecmk
Protein functionCytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1939.6
Molecular mass(da)24145.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 230
	  		  	1    VSRLSAAVVAIDGPAGTGKSSVSRRLARELGARFLDTGAMYRIVTLAVLRAGADPSDIAA   60
			  	61   VETIASTVQMSLGYDPDGDSCYLAGEDVSVEIRGDAVTRAVSAVSSVPAVRTRLVELQRT  120
			  	121  MAEGPGSIVVEGRDIGTVVFPDAPVKIFLTASAETRARRRNAQNVAAGLADDYDGVLADV  180
			  	181  RRRDHLDSTRAVSPLQAAGDAVIVDTSDMTEAEVVAHLLELVTRRSEAVR

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 62 to 220  |  Coverage: 68% Cytidylate_kin Range: 6 to 227  |  Coverage: 96% 1 Range: 1 to 230  |  Coverage: 99% 1
Number of amino acids : 230
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Cytidylate_kinPF0222462-220
Mtb Structural Proteome models
Model Number1
Model nameRv1712
Template1CKE    APDBCREDO
Template coverage5_225
Template Identity(%)38.9
Model coverage(%)96.1
Normalized DOPE score-0.698

Structure Models from Chopin
Model Number1
Profilec.37.1.1 - 3.40.50.300
Click for model details
zscore9.68
Residue begin1
Residue end230
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1712Gene nameConfidence Score
Rv1713engA0.998
Rv1713engA0.998
Rv1711Rv17110.996
Rv1711Rv17110.996
Rv2883cpyrH0.991
Rv1630rpsA0.989
Rv1709scpA0.986
Rv2783cgpsI0.985
Rv2783cgpsI0.985
Rv3227aroA0.985
Rv2783cgpsI0.985
Rv2783cgpsI0.985
Rv2783cgpsI0.985
Rv2445cndkA0.984
Rv1710scpB0.97
Rv1112Rv11120.966
Rv1112Rv11120.966
Rv3602cpanC0.95
Rv3309cupp0.913
Rv1379pyrR0.913
Rv3051cnrdE0.902
Rv3051cnrdE0.902
Rv3051cnrdE0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
poly CPubChem0.978323.197
cytidine diphosphatePubChem0.968403.176
guanosine diphosphatePubChem0.924443.201
polyuridylic acidPubChem0.908324.181
ara-CTPPubChem0.9483.156
cytidine triphosphatePubChem0.9483.156
guanosine triphosphatePubChem0.9523.18
adenosine triphosphatePubChem0.9507.181
ArabinosylcytosinPubChem0.9243.217
cytidinePubChem0.9243.217
cytosine arabinosidePubChem0.9243.217
protiumPubChem0.92.01576
adenosine diphosphatePubChem0.9427.201
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
uridine diphosphatePubChem0.9404.161
dCMPPubChem0.849307.197
hydron sulfatePubChem0.786196.157
sulfatePubChem0.78696.0626