Rv1713

Tuberculist information
Gene nameengA
Protein functionProbable GTP-binding protein EngA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1940.29
Molecular mass(da)49925.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 463
	  		  	1    VTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGV   60
			  	61   TRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGAT  120
			  	121  AADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLD  180
			  	181  GVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDS  240
			  	241  LIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDL  300
			  	301  RVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHK  360
			  	361  LVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLF  420
			  	421  TTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR

Known structures in the PDB
PDB ID1B1B
Total residue count140
Number of chains1
MethodX-RAY
Resolution2.6
PDB ID1FX7
Total residue count920
Number of chains4
MethodX-RAY
Resolution2
PDB ID1U8R
Total residue count1972
Number of chains12
MethodX-RAY
Resolution2.75
PDB ID2ISY
Total residue count314
Number of chains2
MethodX-RAY
Resolution1.96
PDB ID2ISZ
Total residue count694
Number of chains6
MethodX-RAY
Resolution2.4
PDB ID2IT0
Total residue count694
Number of chains6
MethodX-RAY
Resolution2.6
1 47 93 139 185 231 277 323 369 415 461 Range: 28 to 143  |  Coverage: 24% MMR_HSR1 Range: 201 to 319  |  Coverage: 25% MMR_HSR1 Range: 375 to 453  |  Coverage: 16% KH_dom-like Range: 28 to 456  |  Coverage: 92% 1 Range: 1 to 169  |  Coverage: 36% 1 Range: 1 to 169  |  Coverage: 36% 2 Range: 200 to 368  |  Coverage: 36% 3
Number of amino acids : 463
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MMR_HSR1PF0192628-143
MMR_HSR1PF01926201-319
KH_dom-likePF14714375-453
Mtb Structural Proteome models
Model Number1
Model nameRv1713
Template1MKY    APDBCREDO
Template coverage3_439
Template Identity(%)34.0
Model coverage(%)92.4
Normalized DOPE score-0.384

Structure Models from Chopin
Model Number1
Profilec.37.1.8, d.52.5.1 - 3.30.300.20, 3.40.50.300
Click for model details
zscore29.56
Residue begin1
Residue end169
Model Number2
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore13.43
Residue begin1
Residue end169
Model Number3
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore13.43
Residue begin200
Residue end368
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1713Gene nameConfidence Score
Rv1712cmk0.998
Rv1711Rv17110.995
Rv1711Rv17110.995
Rv1709scpA0.98
Rv2783cgpsI0.975
Rv2783cgpsI0.975
Rv2783cgpsI0.975
Rv2783cgpsI0.975
Rv2783cgpsI0.975
Rv1710scpB0.97
Rv2440cobg0.968
Rv2440cobg0.968
Rv2440cobg0.968
Rv2404clepA0.947
Rv2404clepA0.947
Rv2404clepA0.947
Rv2404clepA0.947
Rv2580chisS0.93
Rv2580chisS0.93
Rv2925crnc0.921
Rv2925crnc0.921
Rv2890crpsB0.915
Rv2533cnusB0.909
Rv1406fmt0.907
Rv1406fmt0.907
Rv3442crpsI0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine diphosphatePubChem0.852443.201
selenomethioninePubChem0.843196.106
SeMetPubChem0.782196.106
zincPubChem0.7465.409