Rv1406

Tuberculist information
Gene namefmt
Protein functionProbable methionyl-tRNA formyltransferase Fmt
Functional category(tuberculist)information pathways
Gene location(kb)1582.17
Molecular mass(da)32659.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 312
	  		  	1    VRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQPSPVAREAAERGIPV   60
			  	61   LRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGWVNLHFSLLPAWRGAAP  120
			  	121  VQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAGDLLKRLAVSGAALLSTT  180
			  	181  LDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVERRIRAVTPNPGAWTLIGD  240
			  	241  LRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPVRLGQIQPPGKKLMNAADWA  300
			  	301  RGARLDLAARAT

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 1 to 181  |  Coverage: 57% Formyl_trans_N Range: 204 to 304  |  Coverage: 32% Formyl_trans_C Range: 1 to 311  |  Coverage: 99% 1 Range: 1 to 312  |  Coverage: 99% 1 Range: 1 to 181  |  Coverage: 57% 2 Range: 206 to 304  |  Coverage: 31% 3 Range: 1 to 294  |  Coverage: 93% 4
Number of amino acids : 312
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Formyl_trans_NPF005511-181
Formyl_trans_CPF02911204-304
Mtb Structural Proteome models
Model Number1
Model nameRv1406
Template1FMT    APDBCREDO
Template coverage4_313
Template Identity(%)36.2
Model coverage(%)99.4
Normalized DOPE score-0.578

Structure Models from Chopin
Model Number1
Profileb.46.1.1, c.2.1.2, c.65.1.1
Click for model details
zscore56.48
Residue begin1
Residue end312
Model Number2
Profilec.65.1.1
Click for model details
zscore41.57
Residue begin1
Residue end181
Model Number3
Profile3.10.25.10
Click for model details
zscore23.68
Residue begin206
Residue end304
Model Number4
Profilec.65.1.1 - 3.40.50.170
Click for model details
zscore14.54
Residue begin1
Residue end294
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1406Gene nameConfidence Score
Rv1407fmu0.996
Rv1407fmu0.996
Rv3356cfolD0.993
Rv3356cfolD0.993
Rv2763cdfrA0.99
Rv1408rpe0.984
Rv1007cmetS0.981
Rv0429cdef0.98
Rv1093glyA10.979
Rv0070cglyA20.979
Rv2906ctrmD0.974
Rv2754cthyX0.966
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv0956purN0.952
Rv1389gmk0.948
Rv2882cfrr0.944
Rv2839cinfB0.94
Rv2839cinfB0.94
Rv2839cinfB0.94
Rv2839cinfB0.94
Rv1392metK0.937
Rv1392metK0.937
Rv1392metK0.937
Rv2727cmiaA0.936
Rv2440cobg0.935
Rv2440cobg0.935
Rv2440cobg0.935
Rv1641infC0.932
Rv1641infC0.932
Rv2404clepA0.931
Rv2404clepA0.931
Rv2404clepA0.931
Rv2404clepA0.931
Rv1643rplT0.927
Rv3455ctruA0.926
Rv1010ksgA0.921
Rv1299prfA0.919
Rv1299prfA0.919
Rv2904crplS0.918
Rv2889ctsf0.915
Rv2580chisS0.915
Rv2889ctsf0.915
Rv2580chisS0.915
Rv0389purT0.91
Rv1713engA0.907
Rv1713engA0.907
Rv2211cgcvT0.905
Rv2211cgcvT0.905
Rv1649pheS0.902
Rv1649pheS0.902
Rv2786cribF0.902
Rv2786cribF0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
10-formyltetrahydrofolatePubChem0.967473.439
tetrahydrofolatePubChem0.941445.429
fMetPubChem0.854177.221
magnesiumPubChem0.71724.305
mycobactinPubChem0.705591.61
an aldehydePubChem0.70130.026