SInCRe - Rv1389

Tuberculist information

Gene name	gmk
Protein function	Probable guanylate kinase Gmk
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1564.4
Molecular mass(da)	22063.2
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 208

	  		  	1    VSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPR   60
			  	61   PGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIEV  120
			  	121  DLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVIQRRLDTARIELAAQGDF  180
			  	181  DKVVVNRRLESACAELVSLLVGTAPGSP

Known structures in the PDB

	PDB ID	1S4Q
	Total residue count	228
	Number of chains	1
	Method	X-RAY
	Resolution	2.16

	PDB ID	1Z8F
	Total residue count	228
	Number of chains	1
	Method	X-RAY
	Resolution	2.5

	PDB ID	1ZNW
	Total residue count	207
	Number of chains	1
	Method	X-RAY
	Resolution	2.1

	PDB ID	1ZNX
	Total residue count	207
	Number of chains	1
	Method	X-RAY
	Resolution	2.35

	PDB ID	1ZNY
	Total residue count	207
	Number of chains	1
	Method	X-RAY
	Resolution	2.3

	PDB ID	1ZNZ
	Total residue count	207
	Number of chains	1
	Method	X-RAY
	Resolution	2.5

Number of amino acids : 208

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Guanylate_kin	PF00625	20-202

Mtb Structural Proteome models

Model Number	1
Model name	Rv1389_1s4q_A
Template	1S4Q APDB CREDO
Template coverage	20_202
Template Identity(%)	100.0
Model coverage(%)	87.5
Normalized DOPE score	-1.575

Model Number	2
Model name	Rv1389
Template	1ZNW APDB CREDO
Template coverage	21_201
Template Identity(%)	100.0
Model coverage(%)	86.5
Normalized DOPE score	-1.358

Structure Models from Chopin

Model Number	1
Profile	3.30.63.10 Click for model details
zscore	19.93
Residue begin	52
Residue end	115

Model Number	2
Profile	c.37.1.1 - 3.40.50.300 Click for model details
zscore	11.94
Residue begin	1
Residue end	208

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1389	Gene name	Confidence Score
Rv2584c	apt	0.996
Rv3396c	guaA	0.99
Rv3396c	guaA	0.99
Rv3396c	guaA	0.99
Rv1617	pykA	0.987
Rv1617	pykA	0.987
Rv1391	dfp	0.985
Rv1391	dfp	0.985
Rv2445c	ndkA	0.981
Rv1390	rpoZ	0.973
Rv3624c	hpt	0.973
Rv3313c	add	0.971
Rv2552c	aroE	0.967
Rv2552c	aroE	0.967
Rv3051c	nrdE	0.962
Rv3051c	nrdE	0.962
Rv3051c	nrdE	0.962
Rv0733	adk	0.96
Rv2883c	pyrH	0.955
Rv1406	fmt	0.948
Rv1406	fmt	0.948
Rv3048c	nrdF2	0.943
Rv3247c	tmk	0.942
Rv1341	Rv1341	0.942
Rv2783c	gpsI	0.939
Rv0429c	def	0.939
Rv2783c	gpsI	0.939
Rv2783c	gpsI	0.939
Rv2783c	gpsI	0.939
Rv2783c	gpsI	0.939
Rv1021	Rv1021	0.934
Rv2973c	recG	0.933
Rv2973c	recG	0.933
Rv2973c	recG	0.933
Rv1408	rpe	0.929
Rv1981c	nrdF1	0.925
Rv0570	nrdZ	0.925
Rv0570	nrdZ	0.925
Rv0570	nrdZ	0.925
Rv1392	metK	0.924
Rv1392	metK	0.924
Rv1392	metK	0.924
Rv1388	mihF	0.923
Rv1438	tpi	0.922
Rv2992c	gltS	0.922
Rv1017c	prsA	0.92
Rv1017c	prsA	0.92
Rv0956	purN	0.914
Rv2139	pyrD	0.913
Rv0189c	ilvD	0.911
Rv1699	pyrG	0.911
Rv1699	pyrG	0.911
Rv0357c	purA	0.906

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
guanylatePubChem	0.999	363.221
guanosine diphosphatePubChem	0.996	443.201
formatePubChem	0.98	45.0174
adenosine diphosphatePubChem	0.971	427.201
pyrophosphatePubChem	0.968	177.975
dGMPPubChem	0.956	347.221
dGDPPubChem	0.95	427.201
xanthosine-5'-phosphatePubChem	0.93	364.205
xanthosine monophosphatePubChem	0.92	364.205
adenosine monophosphatePubChem	0.916	347.221
adenosine triphosphatePubChem	0.91	507.181
glutamatePubChem	0.909	147.129
polyglutaminePubChem	0.909	146.145
ammoniaPubChem	0.905	17.0305
glutaminPubChem	0.9	146.145
hydroxyl radicalsPubChem	0.9	17.0073
protiumPubChem	0.9	2.01576
H(+)PubChem	0.9	2.01588
xanthosine 5'-phosphatePubChem	0.9	364.205
guanosine triphosphatePubChem	0.9	523.18
chloridePubChem	0.9	35.453
deuteriumPubChem	0.9	2.01588
potassiumPubChem	0.821	39.0983
sulfatePubChem	0.81	96.0626
guanosinePubChem	0.801	283.241
hydron sulfatePubChem	0.798	196.157
potassium hydridePubChem	0.797	40.1062
SeMetPubChem	0.784	196.106
selenomethioninePubChem	0.784	196.106
phosphatePubChem	0.722	96.9872
acetaldehydePubChem	0.717	44.0526