Rv1392

Tuberculist information
Gene namemetK
Protein functionProbable S-adenosylmethionine synthetase MetK (mat) (AdoMet synthetase) (methionine adenosyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1566.82
Molecular mass(da)43014.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 403
	  		  	1    VSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTTGQVHVVGEVT   60
			  	61   TSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQSPDIAQGVDTAHEARV  120
			  	121  EGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRRLTEVRKNGVLPYLRPDG  180
			  	181  KTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDAST  240
			  	241  VRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR  300
			  	301  WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAIGEVFDLRPGA  360
			  	361  IIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLKRAI

Known structures in the PDB
PDB ID3TDE
Total residue count1632
Number of chains4
MethodX-RAY
Resolution1.85
1 41 81 121 161 201 241 281 321 361 401 Range: 4 to 106  |  Coverage: 25% S-AdoMet_synt_N Range: 128 to 251  |  Coverage: 30% S-AdoMet_synt_M Range: 253 to 392  |  Coverage: 34% S-AdoMet_synt_C Range: 5 to 402  |  Coverage: 98% 1 Range: 253 to 403  |  Coverage: 37% 1 Range: 126 to 292  |  Coverage: 41% 2 Range: 4 to 106  |  Coverage: 25% 3
Number of amino acids : 403
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
S-AdoMet_synt_NPF004384-106
S-AdoMet_synt_MPF02772128-251
S-AdoMet_synt_CPF02773253-392
Mtb Structural Proteome models
Model Number1
Model nameRv1392
Template1RG9    APDBCREDO
Template coverage2_379
Template Identity(%)61.4
Model coverage(%)98.5
Normalized DOPE score-0.456

Structure Models from Chopin
Model Number1
Profiled.130.1.1
Click for model details
zscore27.89
Residue begin253
Residue end403
Model Number2
Profile3.30.300.10
Click for model details
zscore15.56
Residue begin126
Residue end292
Model Number3
Profile3.30.300.10
Click for model details
zscore4.68
Residue begin4
Residue end106
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1392Gene nameConfidence Score
Rv1133cmetE0.999
Rv1133cmetE0.999
Rv2124cmetH0.996
Rv2124cmetH0.996
Rv2124cmetH0.996
Rv2124cmetH0.996
Rv2124cmetH0.996
Rv3248csahH0.994
Rv3248csahH0.994
Rv2458mmuM0.982
Rv0091mtn0.951
Rv1391dfp0.949
Rv1391dfp0.949
Rv2793ctruB0.944
Rv2793ctruB0.944
Rv1617pykA0.94
Rv1617pykA0.94
Rv1406fmt0.937
Rv1406fmt0.937
Rv0350dnaK0.934
Rv1389gmk0.924
Rv3708casd0.923
Rv3708casd0.923
Rv1536ileS0.922
Rv1536ileS0.922
Rv0189cilvD0.92
Rv2445cndkA0.919
Rv2773cdapB0.911
Rv2773cdapB0.911
Rv1438tpi0.907
Rv2540caroF0.904
Rv1408rpe0.904
Rv1079metB0.902
Rv1437pgk0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
S-adenosyl-L-methioninePubChem0.996399.445
L-methioninePubChem0.996149.211
selenomethioninePubChem0.99196.106
pyrophosphatePubChem0.982177.975
phosphatePubChem0.98196.9872
S-adenosylhomocysteinePubChem0.978384.411
SeMetPubChem0.97196.106
5-methyltetrahydrofolatePubChem0.957459.456
S-adenosyl-methioninePubChem0.956398.437
homocysteinePubChem0.956135.185
Se-adenosylselenomethioninePubChem0.952445.332
methyltetrahydrofolatePubChem0.947459.456
tetrahydrofolatePubChem0.939445.429
adenosine triphosphatePubChem0.933507.181
L-homocysteinePubChem0.921135.185
hydroxyl radicalsPubChem0.90717.0073
C04144PubChem0.9703.657
tetrahydropteroyltriglutamatePubChem0.9703.657
H4FPubChem0.9445.429
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
C04489PubChem0.9717.684
protiumPubChem0.92.01576
ethioninePubChem0.87163.238
magnesiumPubChem0.8624.305
AMPPNPPubChem0.822506.196
potassiumPubChem0.80139.0983
S-adenosylethioninePubChem0.772412.464
cycloleucinePubChem0.767129.157
cobaltPubChem0.733117.866
potassium hydridePubChem0.72740.1062
hydron diphosphatePubChem0.727391.981
adenosine diphosphatePubChem0.727427.201
DB03075PubChem0.704256.97
8-bromo-ADPPubChem0.704506.097
hydron; phosphonato phosphatePubChem0.704175.959