Rv2773c

Tuberculist information
Gene namedapB
Protein functionDihydrodipicolinate reductase DapB (DHPR)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3081.6
Molecular mass(da)25733.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 245
	  		  	1    MRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMG   60
			  	61   NLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAA  120
			  	121  RFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGI  180
			  	181  PVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEP  240
			  	241  LLDLH

Known structures in the PDB
No Known structures
1 25 49 73 97 121 145 169 193 217 241 Range: 1 to 105  |  Coverage: 42% DapB_N Range: 108 to 242  |  Coverage: 54% DapB_C Range: 1 to 245  |  Coverage: 99% 1 Range: 2 to 245  |  Coverage: 99% 2
Number of amino acids : 245
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DapB_NPF011131-105
DapB_CPF05173108-242
Mtb Structural Proteome models
Model Number1
Model nameRv2773c_1yl7_A
Template1YL7    APDBCREDO
Template coverage1_245
Template Identity(%)100.0
Model coverage(%)99.6
Normalized DOPE score-1.389

Model Number2
Model nameRv2773c
Template1YL5    APDBCREDO
Template coverage2_245
Template Identity(%)100.0
Model coverage(%)99.2
Normalized DOPE score-1.174

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2773cGene nameConfidence Score
Rv2753cdapA0.999
Rv1293lysA0.997
Rv1293lysA0.997
Rv2726cdapF0.996
Rv3708casd0.981
Rv3708casd0.981
Rv1201cdapD0.969
Rv3709cask0.969
Rv3709cask0.969
Rv3709cask0.969
Rv1201cdapD0.969
Rv3001cilvC0.948
Rv3001cilvC0.948
Rv1202dapE0.938
Rv1202dapE0.938
Rv1383carA0.936
Rv1383carA0.936
Rv1392metK0.911
Rv1392metK0.911
Rv1392metK0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
dipicolinic acidPubChem0.997167.119
NAD+PubChem0.994663.425
tetraethylene glycolPubChem0.991194.226
diaminopimelic acidPubChem0.99190.197
delta1-piperideine-2,6-dicarboxylatePubChem0.987171.151
dihydrodipicolinatePubChem0.987169.135
L-aspartate-beta-semialdehydePubChem0.962117.103
NADP(H)PubChem0.957745.421
L-2,3,4,5-tetrahydrodipicolinatePubChem0.945171.151
deuteriumPubChem0.9062.01588
H(+)PubChem0.9022.01588
coenzyme APubChem0.9767.534
pyruvic acidPubChem0.988.0621
alpha-ketoglutaratePubChem0.9146.098
N-succinyl-L-2-amino-6-oxopimelatePubChem0.9289.239
Co-APubChem0.9767.534
glutamatePubChem0.9147.129
ll-2,6-diaminopimelic acidPubChem0.9190.197
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
succinyl-CoAPubChem0.9867.607
magnesiumPubChem0.924.305
suc-coaPubChem0.9867.607
DB03363PubChem0.8663.425
L-lysinePubChem0.796146.188
NADPPubChem0.725744.413
meso-diaminopimelatePubChem0.711190.197