Rv1202

Tuberculist information
Gene namedapE
Protein functionProbable succinyl-diaminopimelate desuccinylase DapE
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1345.26
Molecular mass(da)37241
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 354
	  		  	1    VLDLRGDPIELTAALIDIPSESRKEARIADEVEAALRAQASGFEIIRNGNAVLARTKLNR   60
			  	61   SSRVLLAGHLDTVPVAGNLPSRRENDQLHGCGAADMKSGDAVFLHLAATLAEPTHDLTLV  120
			  	121  FYDCEEIDSAANGLGRIQRELPDWLSADVAILGEPTAGCIEAGCQGTLRVVLSVTGTRAH  180
			  	181  SARSWLGDNAIHKLGAVLDRLAVYRARSVDIDGCTYREGLSAVRVAGGVAGNVIPDAASV  240
			  	241  TINYRFAPDRSVAAALQHVHDVFDGLDVQIEQTDAAAGALPGLSEPAAKALVEAAGGQVR  300
			  	301  AKYGWTDVSRFAALGIPAVNYGPGDPNLAHCRDERVPVGNITAAVDLLRRYLGG

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 65 to 353  |  Coverage: 81% Peptidase_M20 Range: 163 to 270  |  Coverage: 30% M20_dimer Range: 4 to 352  |  Coverage: 98% 1 Range: 165 to 287  |  Coverage: 34% 1
Number of amino acids : 354
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_M20PF0154665-353
M20_dimerPF07687163-270
Mtb Structural Proteome models
Model Number1
Model nameRv1202
Template1VGY    APDBCREDO
Template coverage2_372
Template Identity(%)24.4
Model coverage(%)98.3
Normalized DOPE score0.161

Structure Models from Chopin
Model Number1
Profile3.30.70.360
Click for model details
zscore14.62
Residue begin165
Residue end287
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1202Gene nameConfidence Score
Rv2726cdapF0.996
Rv2773cdapB0.938
Rv2773cdapB0.938
Rv2753cdapA0.932
Rv0858cdapC0.906
Rv1293lysA0.901
Rv1293lysA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
diaminopimelic acidPubChem0.955190.197
meso-diaminopimelatePubChem0.951190.197
ll-2,6-diaminopimelic acidPubChem0.95190.197
succinatePubChem0.93118.088
glutamatePubChem0.919147.129
N-succinyl-L-2-amino-6-oxopimelatePubChem0.912289.239
L,L-SDAPPubChem0.906290.27
C04421PubChem0.9290.27
alpha-ketoglutaratePubChem0.9146.098
hydroxyl radicalsPubChem0.917.0073