Tuberculist information
Gene namedapF
Protein functionProbable diaminopimelate epimerase DapF (DAP epimerase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3038.93
Molecular mass(da)29697.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 289
	  		  	1    MIFAKGHGTQNDFVLLPDVDAELVLTAARVAALCDRRKGLGADGVLRVTTAGAAQAVGVL   60
			  	61   DSLPEGVRVTDWYMDYRNADGSAAQMCGNGVRVFAHYLRASGLEVRDEFVVGSLAGPRPV  120
			  	121  TCHHVEAAYADVSVDMGKANRLGAGEAVVGGRRFHGLAVDVGNPHLACVDSQLTVDGLAA  180
			  	181  LDVGAPVSFDGAQFPDGVNVEVLTAPVDGAVWMRVHERGVGETRSCGTGTVAAAVAALAA  240
			  	241  VGSPTGTLTVHVPGGEVVVTVTDATSFLRGPSVLVARGDLADDWWNAMG
			  			

Known structures in the PDB
PDB ID3FVE
Total residue count290
Number of chains1
MethodX-RAY
Resolution2.6
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DAP_epimerasePF016783-142
DAP_epimerasePF01678157-275
Mtb Structural Proteome models
Model Number1
Model nameRv2726c_3fve_A
Template3FVE    APDBCREDO
Template coverage0_289
Template Identity(%)100.0
Model coverage(%)100.0
Normalized DOPE score-0.944

Model Number2
Model nameRv2726c
Template2GKE    APDBCREDO
Template coverage1_274
Template Identity(%)26.3
Model coverage(%)97.2
Normalized DOPE score-0.046

Structure Models from Chopin
Model Number1
Profiled.21.1.1
Click for model details
zscore16.97
Residue begin137
Residue end284
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2726cGene nameConfidence Score
Rv1293lysA0.999
Rv1293lysA0.999
Rv1202dapE0.996
Rv1202dapE0.996
Rv2773cdapB0.996
Rv2773cdapB0.996
Rv2753cdapA0.994
Rv2158cmurE0.991
Rv2158cmurE0.991
Rv2158cmurE0.991
Rv3708casd0.969
Rv3708casd0.969
Rv3709cask0.953
Rv3709cask0.953
Rv3709cask0.953
Rv1178Rv11780.935
Rv2727cmiaA0.926
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
diaminopimelic acidPubChem0.989190.197
ll-2,6-diaminopimelic acidPubChem0.982190.197
L-lysinePubChem0.974146.188
glycerolPubChem0.96592.0938
meso-diaminopimelatePubChem0.957190.197
succinatePubChem0.927118.088
carbon dioxidePubChem0.91744.0095
hydroxyl radicalsPubChem0.90517.0073
dithiothreitolPubChem0.9154.251
threo-1,4-dimercapto-2,3-butanediolPubChem0.9154.251
L-2,3,4,5-tetrahydrodipicolinatePubChem0.9171.151
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
L,L-SDAPPubChem0.9290.27
delta1-piperideine-2,6-dicarboxylatePubChem0.9171.151
deuteriumPubChem0.92.01588
C04421PubChem0.9290.27
alpha-ketoglutaratePubChem0.9146.098
poly-L-lysine hydrobromidePubChem0.9146.188
glutamatePubChem0.9147.129