SInCRe - Rv3708c

Tuberculist information

Gene name	asd
Protein function	Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic semialdehyde dehydrogenase) (L-aspartate-beta-semialdehyde dehydrogenase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	4151.18
Molecular mass(da)	36230.2
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 345

	  		  	1    MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETA   60
			  	61   DPSGLDIALFSAGSAMSKVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRR  120
			  	121  PKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVSGSGLAGVAELAEQARAVIGG  180
			  	181  AEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPD  240
			  	241  LLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDES  300
			  	301  LVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLTADL

Known structures in the PDB

	PDB ID	3TZ6
	Total residue count	344
	Number of chains	1
	Method	X-RAY
	Resolution	1.95

	PDB ID	3VOS
	Total residue count	362
	Number of chains	1
	Method	X-RAY
	Resolution	2.18

Number of amino acids : 345

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Semialdhyde_dh	PF01118	4-119
Semialdhyde_dhC	PF02774	139-328

Mtb Structural Proteome models

Model Number	1
Model name	Rv3708c
Template	1YS4 APDB CREDO
Template coverage	7_353
Template Identity(%)	27.0
Model coverage(%)	99.7
Normalized DOPE score	0.548

Structure Models from Chopin

Model Number	1
Profile	d.81.1.1 Click for model details
zscore	18.1
Residue begin	139
Residue end	328

Model Number	2
Profile	c.2.1.3, d.81.1.1 - 3.30.360.10, 3.40.50.720 Click for model details
zscore	12.06
Residue begin	3
Residue end	345

Model Number	3
Profile	c.2.1.12 Click for model details
zscore	5.51
Residue begin	4
Residue end	119

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3708c	Gene name	Confidence Score
Rv3709c	ask	0.999
Rv3709c	ask	0.999
Rv3709c	ask	0.999
Rv2753c	dapA	0.998
Rv1294	thrA	0.997
Rv1294	thrA	0.997
Rv1294	thrA	0.997
Rv1293	lysA	0.99
Rv1293	lysA	0.99
Rv2995c	leuB	0.983
Rv2773c	dapB	0.981
Rv2773c	dapB	0.981
Rv2726c	dapF	0.969
Rv1296	thrB	0.964
Rv1296	thrB	0.964
Rv1295	thrC	0.962
Rv2538c	aroB	0.958
Rv2987c	leuD	0.951
Rv1658	argG	0.949
Rv2540c	aroF	0.946
Rv2988c	leuC	0.945
Rv1392	metK	0.923
Rv1654	argB	0.923
Rv1392	metK	0.923
Rv1392	metK	0.923
Rv0189c	ilvD	0.918
Rv1659	argH	0.917
Rv1659	argH	0.917
Rv0500	proC	0.916
Rv0500	proC	0.916
Rv3455c	truA	0.913
Rv1437	pgk	0.91
Rv2210c	ilvE	0.909
Rv1612	trpB	0.904
Rv1652	argC	0.904
Rv1652	argC	0.904
Rv3396c	guaA	0.902
Rv3396c	guaA	0.902
Rv3396c	guaA	0.902
Rv2678c	hemE	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
phosphatePubChem	0.994	96.9872
L-aspartate-beta-semialdehydePubChem	0.989	117.103
NADPPubChem	0.982	744.413
homoserinePubChem	0.965	119.119
aspartatePubChem	0.945	133.103
aspartyl phosphatePubChem	0.945	213.083
L-homoserinePubChem	0.939	119.119
hydron diphosphatePubChem	0.939	391.981
deuteriumPubChem	0.911	2.01588
H(+)PubChem	0.911	2.01588
NADP(H)PubChem	0.904	745.421
hydron; phosphonato phosphatePubChem	0.9	175.959
potassium aspartatePubChem	0.9	133.103
dihydrodipicolinatePubChem	0.9	169.135
pyruvic acidPubChem	0.9	88.0621
adenosine triphosphatePubChem	0.9	507.181
beta-aspartyl phosphatePubChem	0.9	213.083
glycerolPubChem	0.9	92.0938
protiumPubChem	0.9	2.01576
hydroxyl radicalsPubChem	0.9	17.0073
pyrophosphatePubChem	0.9	177.975
adenosine diphosphatePubChem	0.9	427.201
diaminopimelic acidPubChem	0.808	190.197
malonatePubChem	0.765	104.061
selenomethioninePubChem	0.76	196.106
SeMetPubChem	0.76	196.106
adenosine 2',5'-bisphosphatePubChem	0.7	427.201
2',5'-ADPPubChem	0.7	427.201