Rv1659

Tuberculist information
Gene nameargH
Protein functionProbable argininosuccinate lyase ArgH
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1872.64
Molecular mass(da)49742.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 470
	  		  	1    VSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLFRAGLLTEEQR   60
			  	61   DGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAA  120
			  	121  LFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKTHLQSAQPILLAHHLLAHAHP  180
			  	181  LLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFA  240
			  	241  AEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK  300
			  	301  SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVQR  360
			  	361  MAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAAEQRGVGLQELTDDELAAISP  420
			  	421  ELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIGEAAERLRRQLVR

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 11 to 306  |  Coverage: 62% Lyase_1 Range: 369 to 438  |  Coverage: 14% ASL_C2 Range: 8 to 461  |  Coverage: 96% 1 Range: 1 to 470  |  Coverage: 99% 1
Number of amino acids : 470
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Lyase_1PF0020611-306
ASL_C2PF14698369-438
Mtb Structural Proteome models
Model Number1
Model nameRv1659
Template1TJ7    APDBCREDO
Template coverage3_456
Template Identity(%)41.2
Model coverage(%)96.4
Normalized DOPE score-0.393

Structure Models from Chopin
Model Number1
Profilea.127.1.1
Click for model details
zscore39.49
Residue begin1
Residue end470
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1659Gene nameConfidence Score
Rv1658argG0.999
Rv1656argF0.998
Rv1656argF0.998
Rv1653argJ0.996
Rv1652argC0.995
Rv1652argC0.995
Rv1654argB0.993
Rv2747argA0.989
Rv1655argD0.987
Rv1384carB0.986
Rv1384carB0.986
Rv1384carB0.986
Rv1384carB0.986
Rv1383carA0.976
Rv1383carA0.976
Rv0777purB0.957
Rv0777purB0.957
Rv1657argR0.95
Rv1657argR0.95
Rv0896gltA20.938
Rv1293lysA0.936
Rv1293lysA0.936
Rv1001arcA0.931
Rv2427cproA0.918
Rv3708casd0.917
Rv3708casd0.917
Rv1240mdh0.902
Rv1240mdh0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
argininosuccinatePubChem0.993290.273
L-argininePubChem0.993174.201
citrullinePubChem0.981175.186
ornithinePubChem0.972132.161
argininosuccinic acidPubChem0.969290.273
fumaratePubChem0.966116.072
adenylosuccinatePubChem0.957463.293
arginino-succinatePubChem0.949290.273
aspartatePubChem0.926133.103
adenosine monophosphatePubChem0.925347.221
urea solutionPubChem0.91360.0553
deuteriumPubChem0.9072.01588
H(+)PubChem0.9042.01588
pyrophosphatePubChem0.9177.975
protiumPubChem0.92.01576
argininPubChem0.9174.201
adenosine triphosphatePubChem0.9507.181
citrullinPubChem0.9175.186
potassium aspartatePubChem0.9133.103
hydroxyl radicalsPubChem0.917.0073
dexamethasonePubChem0.817392.461
vinyl fluoridePubChem0.72146.0436
phosphatePubChem0.70296.9872
glycerolPubChem0.70192.0938