Rv2747

Tuberculist information
Gene nameargA
Protein functionProbable L-glutamate alpha-N-acetyltranferase ArgA (alpha-N-acetylglutamate synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3059.26
Molecular mass(da)19556.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 174
	  		  	1    VTERPRDCRPVVRRARTSDVPAIKQLVDTYAGKILLEKNLVTLYEAVQEFWVAEHPDLYG   60
			  	61   KVVGCGALHVLWSDLGEIRTVAVDPAMTGHGIGHAIVDRLLQVARDLQLQRVFVLTFETE  120
			  	121  FFARHGFTEIEGTPVTAEVFDEMCRSYDIGVAEFLDLSYVKPNILGNSRMLLVL

Known structures in the PDB
No Known structures
1 18 35 52 69 86 103 120 137 154 171 Range: 57 to 129  |  Coverage: 41% Acetyltransf_1 Range: 7 to 156  |  Coverage: 85% 1 Range: 1 to 174  |  Coverage: 99% 1
Number of amino acids : 174
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acetyltransf_1PF0058357-129
Mtb Structural Proteome models
Model Number1
Model nameRv2747
Template1NSL    APDBCREDO
Template coverage7_179
Template Identity(%)22.0
Model coverage(%)85.6
Normalized DOPE score0.667

Structure Models from Chopin
Model Number1
Profile3.40.630.30
Click for model details
zscore13.27
Residue begin1
Residue end174
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2747Gene nameConfidence Score
Rv1654argB0.995
Rv1653argJ0.991
Rv1659argH0.989
Rv1659argH0.989
Rv1658argG0.971
Rv1656argF0.931
Rv1656argF0.931
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamatePubChem0.922147.129
N-acetylglutamatePubChem0.9189.166