Rv1658

Tuberculist information
Gene nameargG
Protein functionProbable argininosuccinate synthase ArgG
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1871.36
Molecular mass(da)43682.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 398
	  		  	1    MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEHMDVIRQRALDCGAVEAV   60
			  	61   VVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAHGCTG  120
			  	121  KGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNV  180
			  	181  WGRAVETGFLEHLWNAPTKDIYAYTEDPTINWGVPDEVIVGFERGVPVSVDGKPVSMLAA  240
			  	241  IEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFK  300
			  	301  RQTDQRWAELVYDGLWYSPLKAALEAFVAKTQEHVSGEVRLVLHGGHIAVNGRRSAESLY  360
			  	361  DFNLATYDEGDSFDQSAARGFVYVHGLSSKLAARRDLR

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 6 to 393  |  Coverage: 97% Arginosuc_synth Range: 2 to 391  |  Coverage: 97% 1 Range: 142 to 397  |  Coverage: 64% 1
Number of amino acids : 398
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Arginosuc_synthPF007646-393
Mtb Structural Proteome models
Model Number1
Model nameRv1658
Template1VL2    APDBCREDO
Template coverage2_399
Template Identity(%)40.5
Model coverage(%)97.7
Normalized DOPE score-0.449

Structure Models from Chopin
Model Number1
Profile3.90.1260.10
Click for model details
zscore48.55
Residue begin142
Residue end397
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1658Gene nameConfidence Score
Rv1656argF0.999
Rv1656argF0.999
Rv1653argJ0.999
Rv1659argH0.999
Rv1659argH0.999
Rv1652argC0.997
Rv1384carB0.997
Rv1652argC0.997
Rv1384carB0.997
Rv1384carB0.997
Rv1384carB0.997
Rv1655argD0.997
Rv1654argB0.996
Rv1383carA0.99
Rv1383carA0.99
Rv3709cask0.989
Rv3709cask0.989
Rv3709cask0.989
Rv1380pyrB0.987
Rv1380pyrB0.987
Rv0357cpurA0.981
Rv1657argR0.98
Rv1657argR0.98
Rv2439cproB0.976
Rv2439cproB0.976
Rv2747argA0.971
Rv2201asnB0.955
Rv2201asnB0.955
Rv3708casd0.949
Rv3708casd0.949
Rv0808purF0.929
Rv0808purF0.929
Rv1538cansA0.928
Rv1293lysA0.924
Rv1293lysA0.924
Rv2995cleuB0.919
Rv0500proC0.919
Rv0500proC0.919
Rv0809purM0.918
Rv0809purM0.918
Rv2139pyrD0.914
Rv1001arcA0.914
Rv1599hisD0.908
Rv2589gabT0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
argininosuccinatePubChem0.998290.273
citrullinePubChem0.998175.186
L-argininePubChem0.992174.201
aspartatePubChem0.991133.103
ornithinePubChem0.988132.161
adenosine triphosphatePubChem0.975507.181
carbamoyl phosphatePubChem0.97141.02
adenosine monophosphatePubChem0.969347.221
argininosuccinic acidPubChem0.966290.273
arginino-succinatePubChem0.963290.273
phosphatePubChem0.9596.9872
fumaratePubChem0.932116.072
citrullinPubChem0.918175.186
pyrophosphatePubChem0.915177.975
H(+)PubChem0.9112.01588
deuteriumPubChem0.912.01588
potassium aspartatePubChem0.9133.103
protiumPubChem0.92.01576
argininPubChem0.9174.201
sulfatePubChem0.81296.0626
succinatePubChem0.791118.088
hydron sulfatePubChem0.759196.157
ammoniaPubChem0.74917.0305
magnesiumPubChem0.71224.305
AMPPNPPubChem0.7506.196
hydron; succinatePubChem0.7119.096
DB02267PubChem0.7290.273