Rv1001

Tuberculist information
Gene namearcA
Protein functionProbable arginine deiminase ArcA (adi) (ad) (arginine dihydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1117.19
Molecular mass(da)43057.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 402
	  		  	1    VGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWVSRAQDEHDEFAELLA   60
			  	61   SRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRLGLPLAQELSAYLRSLDPGRLAHV  120
			  	121  LTAGMTFNELPSDTRTDVSLVLRMHHGGDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALR  180
			  	181  ARVREASLTDLIYAHHPRFTGVRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAE  240
			  	241  ALARSLFDDDLAHTVLAVPIAQQRAQMHLDTVCTMVDTDTMVMYANVVDTLEAFTIQRTP  300
			  	301  DGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPVVAEREQWDDGNNTLALAPGVVVAYER  360
			  	361  NVQTNARLQDAGIEVLTIAGSELGTGRGGPRCMSCPAARDPL

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 19 to 399  |  Coverage: 94% Amidinotransf Range: 3 to 402  |  Coverage: 99% 1 Range: 1 to 402  |  Coverage: 99% 1
Number of amino acids : 402
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AmidinotransfPF0227419-399
Mtb Structural Proteome models
Model Number1
Model nameRv1001
Template2A9G    APDBCREDO
Template coverage6_416
Template Identity(%)38.2
Model coverage(%)99.3
Normalized DOPE score-0.335

Structure Models from Chopin
Model Number1
Profiled.126.1.4
Click for model details
zscore62
Residue begin1
Residue end402
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1001Gene nameConfidence Score
Rv1656argF0.998
Rv1656argF0.998
Rv2531cRv2531c0.985
Rv2531cRv2531c0.985
Rv2343cdnaG0.966
Rv2343cdnaG0.966
Rv2343cdnaG0.966
Rv2343cdnaG0.966
Rv2343cdnaG0.966
Rv1848ureA0.963
Rv1657argR0.941
Rv1657argR0.941
Rv1659argH0.931
Rv1659argH0.931
Rv1658argG0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-argininePubChem0.989174.201
citrullinePubChem0.977175.186
ornithinePubChem0.977132.161
carbamoyl phosphatePubChem0.972141.02
ammoniaPubChem0.9717.0305
phosphatePubChem0.91696.9872
H(+)PubChem0.9052.01588
deuteriumPubChem0.9042.01588
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
argininPubChem0.9174.201
citrullinPubChem0.9175.186
butylparabenPubChem0.741194.227
nitratePubChem0.7462.0049
O-ureido-L-homoserinePubChem0.733177.159
fumaratePubChem0.728116.072