Rv2531c

Tuberculist information
Gene nameRv2531c
Protein functionProbable amino acid decarboxylase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2854.94
Molecular mass(da)106029
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 947
	  		  	1    MNPNSVRPRRLHVSALAAVANPSYTRLDTWNLLDDACRHLAEVDLAGLDTTHDVARAKRL   60
			  	61   MDRIGAYERYWLYPGAQNLATFRAHLDSHSTVRLTEEVSLAVRLLSEYGDRTALFDTSAS  120
			  	121  LAEQELVAQAKQQQFYTVLLADDSPATAPDSLAECLRQLRNPADEVQFELLVVASIEDAI  180
			  	181  TAVALNGEIQAAIIRHDLPLRSRDRVPLMTTLLGTDGDEAVANETHDWVECAEWIRELRP  240
			  	241  HIDLYLLTDESIAAETQDEPDVYDRTFYRLNDVTDLHSTVLAGLRNRYATPFFDALRAYA  300
			  	301  AAPVGQFHALPVARGASIFNSKSLHDMGEFYGRNIFMAETSTTSGGLDSLLDPHGNIKTA  360
			  	361  MDKAAVTWNANQTYFVTNGTSTANKIVVQALTRPGDIVLIDRNCHKSHHYGLVLAGAYPM  420
			  	421  YLDAYPLPQYAIYGAVPLRTIKQALLDLEAAGQLHRVRMLLLTNCTFDGVVYNPRRVMEE  480
			  	481  VLAIKPDICFLWDEAWYAFATAVPWARQRTAMIAAERLEQMLSTAEYAEEYRNWCASMDG  540
			  	541  VDRSEWVDHRLLPDPNRARVRVYATHSTHKSLSALRQASMIHVRDQDFKALTRDAFGEAF  600
			  	601  LTHTSTSPNQQLLASLDLARRQVDIEGFELVRHVYNMALVFRHRVRKDRLISKWFRILDE  660
			  	661  SDLVPDAFRSSTVSSYRQVRQGALADWNEAWRSDQFVLDPTRLTLFIGATGMNGYDFREK  720
			  	721  ILMERFGIQINKTSINSVLLIFTIGVTWSSVHYLLDVLRRVAIDLDRSQKAASGADLALH  780
			  	781  RRHVEEITQDLPHLPDFSEFDLAFRPDDASSFGDMRSAFYAGYEEADREYVQIGLAGRRL  840
			  	841  AEGKTLVSTTFVVPYPPGFPVLVPGQLVSKEIIYFLAQLDVKEIHGYNPDLGLSVFTQAA  900
			  	901  LARMEAARNAVATVGAALPAFEVPRDASALNGTVNGDSVLQGVAEDA

Known structures in the PDB
No Known structures
1 95 189 283 377 471 565 659 753 847 941 Range: 291 to 526  |  Coverage: 24% OKR_DC_1 Range: 548 to 750  |  Coverage: 21% OKR_DC_1 Range: 820 to 895  |  Coverage: 7% OKR_DC_1_C Range: 194 to 932  |  Coverage: 77% 1 Range: 1 to 237  |  Coverage: 24% 1 Range: 820 to 895  |  Coverage: 7% 2 Range: 1 to 237  |  Coverage: 24% 3 Range: 290 to 526  |  Coverage: 24% 4 Range: 548 to 784  |  Coverage: 24% 5
Number of amino acids : 947
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
OKR_DC_1PF01276291-526
OKR_DC_1PF01276548-750
OKR_DC_1_CPF03711820-895
Mtb Structural Proteome models
Model Number1
Model nameRv2531c
Template1C4K    APDBCREDO
Template coverage12_730
Template Identity(%)18.6
Model coverage(%)77.9
Normalized DOPE score0.872

Structure Models from Chopin
Model Number1
Profilec.23.1.4, c.67.1.5, d.125.1.1 - 3.40.50.220, 3.40.640.10, 3.90.100.10, 3.90.1150.10
Click for model details
zscore21.58
Residue begin1
Residue end237
Model Number2
Profile3.90.100.10
Click for model details
zscore15.95
Residue begin820
Residue end895
Model Number3
Profilec.67.1.5
Click for model details
zscore15.17
Residue begin1
Residue end237
Model Number4
Profilec.67.1.5
Click for model details
zscore15.17
Residue begin290
Residue end526
Model Number5
Profilec.67.1.5
Click for model details
zscore15.17
Residue begin548
Residue end784
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2531cGene nameConfidence Score
Rv1001arcA0.985
Rv1722Rv17220.934
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
putrescinePubChem0.91388.1515
L-argininePubChem0.906174.201
spermidinePubChem0.906145.246
ornithinePubChem0.905132.161
agmatinePubChem0.903130.191
ammoniaPubChem0.90117.0305
glutamatePubChem0.901147.129
gamma-glutamylputrescinePubChem0.9217.265
adenosine diphosphatePubChem0.9427.201
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
phosphatePubChem0.996.9872
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
decarboxylated S-adenosylmethioninePubChem0.9355.436
alpha-ketoglutaratePubChem0.9146.098
urea solutionPubChem0.960.0553
5'-deoxy-5'-methylthioadenosinePubChem0.9297.333
argininPubChem0.9174.201
hydroxyl radicalsPubChem0.917.0073
methylthioadenosinePubChem0.9297.333
C15699PubChem0.9217.265
carbon dioxidePubChem0.944.0095
gamma-aminobutyraldehydePubChem0.987.1204
N-carbamoylputrescinePubChem0.9131.176