Rv0809

Tuberculist information
Gene namepurM
Protein functionProbable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)903.725
Molecular mass(da)38393.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 364
	  		  	1    MTDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFT   60
			  	61   LRGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIA  120
			  	121  VGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVGVVEADNVL  180
			  	181  GPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRI  240
			  	241  YAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGR  300
			  	301  VRRTEMEKTFNMGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQ  360
			  	361  HPRF

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 53 to 152  |  Coverage: 27% AIRS Range: 186 to 356  |  Coverage: 46% AIRS_C Range: 15 to 357  |  Coverage: 93% 1 Range: 27 to 359  |  Coverage: 91% 1 Range: 186 to 356  |  Coverage: 46% 2 Range: 18 to 181  |  Coverage: 44% 3
Number of amino acids : 364
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AIRSPF0058653-152
AIRS_CPF02769186-356
Mtb Structural Proteome models
Model Number1
Model nameRv0809
Template1CLI    APDBCREDO
Template coverage5_344
Template Identity(%)45.9
Model coverage(%)94.0
Normalized DOPE score-0.405

Structure Models from Chopin
Model Number1
Profile3.30.1330.10, 3.90.650.10
Click for model details
zscore70.55
Residue begin27
Residue end359
Model Number2
Profile3.90.650.10
Click for model details
zscore27.33
Residue begin186
Residue end356
Model Number3
Profile3.30.1330.10
Click for model details
zscore18.13
Residue begin18
Residue end181
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0809Gene nameConfidence Score
Rv0808purF0.999
Rv0808purF0.999
Rv0956purN0.998
Rv0772purD0.998
Rv0772purD0.998
Rv0772purD0.998
Rv3276cpurK0.997
Rv0788purQ0.997
Rv0803purL0.997
Rv0803purL0.997
Rv3275cpurE0.995
Rv0787ARv0787A0.992
Rv0957purH0.991
Rv0957purH0.991
Rv3396cguaA0.979
Rv3396cguaA0.979
Rv3396cguaA0.979
Rv0357cpurA0.978
Rv0780purC0.975
Rv0777purB0.974
Rv0777purB0.974
Rv0389purT0.956
Rv1605hisF0.933
Rv3411cguaB20.923
Rv3411cguaB20.923
Rv1658argG0.918
Rv2139pyrD0.904
Rv3356cfolD0.902
Rv3356cfolD0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
5-aminoimidazole ribonucleotidePubChem0.968295.186
5'-phosphoribosylformylglycinamidinePubChem0.957313.202
FGARPubChem0.955314.186
FGAMPubChem0.953312.194
formylglycinamide ribonucleotidePubChem0.953314.186
phosphatePubChem0.92896.9872
adenosine triphosphatePubChem0.925507.181
5'-phosphoribosyl-N-formylglycinamidePubChem0.916314.186
adenosine diphosphatePubChem0.912427.201
glutamatePubChem0.911147.129
protiumPubChem0.92.01576
N5-CAIRPubChem0.9339.196
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
polyglutaminePubChem0.9146.145
bicarbonatePubChem0.962.0248
glutaminPubChem0.9146.145
hydroxyl radicalsPubChem0.917.0073
phosphoribosylaminoimidazolePubChem0.9294.178
sulfatePubChem0.81596.0626
adenosine monophosphatePubChem0.807347.221
hydron sulfatePubChem0.791196.157
glycerolPubChem0.75292.0938
SeMetPubChem0.75196.106
selenomethioninePubChem0.745196.106
hydride acetatePubChem0.71861.0599
acetatePubChem0.71859.044
formatePubChem0.70545.0174
polyethylene glycolPubChem0.70262.0678
ethylene glycol; hydronPubChem0.70263.0758
citratePubChem0.701192.124