Rv0357c

Tuberculist information
Gene namepurA
Protein functionProbable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)435.471
Molecular mass(da)46822.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 432
	  		  	1    MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGV   60
			  	61   LTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAHLLMPYHIAIDKVTERY  120
			  	121  MGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEAACEFKNQVLVKIYNRKA  180
			  	181  LDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTS  240
			  	241  SNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT  300
			  	301  TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEIDGRRTRDMPMT  360
			  	361  QRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLRLEQLAGAPVSCIGVGPGREQ  420
			  	421  TIVRRDVLQDRP

Known structures in the PDB
No Known structures
1 44 87 130 173 216 259 302 345 388 431 Range: 3 to 423  |  Coverage: 97% Adenylsucc_synt Range: 3 to 429  |  Coverage: 98% 1
Number of amino acids : 432
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Adenylsucc_syntPF007093-423
Mtb Structural Proteome models
Model Number1
Model nameRv0357c
Template1ADE    APDBCREDO
Template coverage3_430
Template Identity(%)50.8
Model coverage(%)98.6
Normalized DOPE score-0.739

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0357cGene nameConfidence Score
Rv0777purB0.999
Rv0777purB0.999
Rv0957purH0.998
Rv0957purH0.998
Rv3624chpt0.997
Rv3411cguaB20.992
Rv3411cguaB20.992
Rv1380pyrB0.99
Rv1380pyrB0.99
Rv1658argG0.981
Rv0809purM0.978
Rv0809purM0.978
Rv0808purF0.973
Rv0808purF0.973
Rv0772purD0.972
Rv1843cguaB10.972
Rv0772purD0.972
Rv1843cguaB10.972
Rv0772purD0.972
Rv3396cguaA0.967
Rv3396cguaA0.967
Rv3396cguaA0.967
Rv1699pyrG0.961
Rv1699pyrG0.961
Rv1595nadB0.958
Rv1595nadB0.958
Rv3275cpurE0.951
Rv1383carA0.947
Rv1383carA0.947
Rv0956purN0.945
Rv1449ctkt0.944
Rv0733adk0.944
Rv1449ctkt0.944
Rv1449ctkt0.944
Rv2580chisS0.94
Rv2580chisS0.94
Rv0780purC0.939
Rv3601cpanD0.931
Rv1341Rv13410.931
Rv1653argJ0.926
Rv1617pykA0.925
Rv1617pykA0.925
Rv1656argF0.922
Rv1656argF0.922
Rv1017cprsA0.921
Rv1017cprsA0.921
Rv0056rplI0.921
Rv0056rplI0.921
Rv2201asnB0.913
Rv0803purL0.913
Rv0803purL0.913
Rv2201asnB0.913
Rv1538cansA0.91
Rv1021Rv10210.908
Rv3443crplM0.906
Rv1389gmk0.906
Rv2992cgltS0.904
Rv2584capt0.903
Rv3442crpsI0.902
Rv3410cguaB30.902
Rv3709cask0.901
Rv3709cask0.901
Rv3709cask0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
inosine monophosphatePubChem0.996348.206
adenosine monophosphatePubChem0.994347.221
adenylosuccinatePubChem0.987463.293
magnesiumPubChem0.9824.305
guanosine diphosphatePubChem0.979443.201
phosphatePubChem0.97996.9872
aspartatePubChem0.952133.103
guanosine triphosphatePubChem0.931523.18
fumaratePubChem0.904116.072
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
CHEBI:15919PubChem0.9463.293
potassium aspartatePubChem0.9133.103
hydroxyl radicalsPubChem0.917.0073
FAIPubChem0.9366.221
5-formamidoimidazole-4-carboxamide ribotidePubChem0.9366.221
hadacidinPubChem0.887119.076
IMOPubChem0.793428.186
nitratePubChem0.7962.0049
hypoxanthinePubChem0.785136.111
pyrophosphatePubChem0.774177.975
adeninePubChem0.774135.127
sulfatePubChem0.74196.0626
L023991PubChem0.741412.186
[9-[(2R,4S,5R)-4-hydroxy-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl] dihydrogen phosphatePubChem0.741412.186
hydron diphosphatePubChem0.741391.981
hydron sulfatePubChem0.741196.157
hydantocidin 5'-monophosphatePubChem0.728298.144
PG6PubChem0.704266.331
Gpp(NH)pPubChem0.703522.196
aminophosphonic acid-guanylate esterPubChem0.703442.216
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.703521.208
1qf5PubChem0.703459.3
2-mercaptoethanolPubChem0.70378.1334
RPDPubChem0.703459.3
Na(+)PubChem0.70322.9898
[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinimylPubChem0.703442.216
hydron; phosphonato phosphatePubChem0.703175.959
1ch8PubChem0.703505.165
1qf4PubChem0.703459.3