Rv1843c

Tuberculist information
Gene nameguaB1
Protein functionProbable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2092.26
Molecular mass(da)49932.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 479
	  		  	1    VMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTTIPVVVANMTAVAGRR   60
			  	61   MAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVTLAPDDSVSDAMALIHKRA  120
			  	121  HGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVTAPAGTEPRKIFDLLEHAPVD  180
			  	181  VAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRIGAAVGINGDVGAKARALAEAGV  240
			  	241  DVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVGPG  300
			  	301  AMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALALAAGASNVMIGS  360
			  	361  WFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGADNPFDRARKALFEEGISTSRM  420
			  	421  GLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHERAVVGVQSGAGFAEGHPLPAGW

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 12 to 475  |  Coverage: 96% IMPDH Range: 93 to 145  |  Coverage: 10% CBS Range: 150 to 204  |  Coverage: 11% CBS Range: 11 to 474  |  Coverage: 96% 1 Range: 7 to 467  |  Coverage: 96% 1 Range: 146 to 399  |  Coverage: 52% 2
Number of amino acids : 479
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IMPDHPF0047812-475
CBSPF0057193-145
CBSPF00571150-204
Mtb Structural Proteome models
Model Number1
Model nameRv1843c
Template1ZFJ    APDBCREDO
Template coverage12_478
Template Identity(%)38.6
Model coverage(%)96.7
Normalized DOPE score-0.073

Structure Models from Chopin
Model Number1
Profilec.1.5.1 - 3.20.20.70
Click for model details
zscore46.73
Residue begin7
Residue end467
Model Number2
Profilec.1.31.1 - 3.20.20.70
Click for model details
zscore10.72
Residue begin146
Residue end399
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1843cGene nameConfidence Score
Rv3396cguaA0.999
Rv3396cguaA0.999
Rv3396cguaA0.999
Rv0357cpurA0.972
Rv0957purH0.972
Rv0957purH0.972
Rv3410cguaB30.968
Rv3624chpt0.94
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
inosine monophosphatePubChem0.98348.206
guanylatePubChem0.964363.221
xanthosine monophosphatePubChem0.947364.205
xanthosine 5'-phosphatePubChem0.924364.205
NAD+PubChem0.915663.425
H(+)PubChem0.9072.01588
adenosine monophosphatePubChem0.905347.221
5-formamidoimidazole-4-carboxamide ribotidePubChem0.903366.221
deuteriumPubChem0.9032.01588
adenosine triphosphatePubChem0.9507.181
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
polyglutaminePubChem0.9146.145
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
glutamatePubChem0.9147.129
pyrophosphatePubChem0.9177.975
xanthosine-5'-phosphatePubChem0.9364.205
FAIPubChem0.9366.221
ammoniaPubChem0.917.0305
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
glutaminPubChem0.9146.145