Rv3396c

Tuberculist information
Gene nameguaA
Protein functionProbable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3812.5
Molecular mass(da)56027.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 525
	  		  	1    VVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVA   60
			  	61   LVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTEL  120
			  	121  KVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHP  180
			  	181  EVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAV  240
			  	241  AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVS  300
			  	301  APEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNV  360
			  	361  GGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRL  420
			  	421  DTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDA  480
			  	481  MTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 18 to 199  |  Coverage: 34% GATase Range: 209 to 309  |  Coverage: 19% NAD_synthase Range: 431 to 524  |  Coverage: 17% GMP_synt_C Range: 16 to 525  |  Coverage: 96% 1 Range: 10 to 525  |  Coverage: 98% 1 Range: 206 to 525  |  Coverage: 60% 2 Range: 404 to 525  |  Coverage: 23% 3 Range: 18 to 199  |  Coverage: 34% 4 Range: 209 to 309  |  Coverage: 19% 5 Range: 201 to 443  |  Coverage: 46% 6
Number of amino acids : 525
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATasePF0011718-199
NAD_synthasePF02540209-309
GMP_synt_CPF00958431-524
Mtb Structural Proteome models
Model Number1
Model nameRv3396c
Template1GPM    APDBCREDO
Template coverage9_525
Template Identity(%)48.5
Model coverage(%)97.0
Normalized DOPE score-0.385

Structure Models from Chopin
Model Number1
Profilec.23.16.1, c.26.2.1, d.52.2.1 - 3.30.300.10, 3.40.50.620, 3.40.50.880
Click for model details
zscore89.03
Residue begin10
Residue end525
Model Number2
Profile3.30.300.10, 3.40.50.620
Click for model details
zscore56.37
Residue begin206
Residue end525
Model Number3
Profiled.52.2.1
Click for model details
zscore26.01
Residue begin404
Residue end525
Model Number4
Profilec.23.16.1 - 3.40.50.880
Click for model details
zscore20.48
Residue begin18
Residue end199
Model Number5
Profilec.26.2.1 - 3.40.50.620
Click for model details
zscore14.13
Residue begin209
Residue end309
Model Number6
Profilec.26.2.5
Click for model details
zscore10.42
Residue begin201
Residue end443
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3396cGene nameConfidence Score
Rv1843cguaB10.999
Rv3411cguaB20.999
Rv1843cguaB10.999
Rv3411cguaB20.999
Rv3624chpt0.995
Rv1699pyrG0.992
Rv1699pyrG0.992
Rv3410cguaB30.992
Rv2584capt0.992
Rv1389gmk0.99
Rv0808purF0.99
Rv0808purF0.99
Rv0957purH0.986
Rv0957purH0.986
Rv0809purM0.979
Rv0809purM0.979
Rv0772purD0.978
Rv0772purD0.978
Rv0772purD0.978
Rv0777purB0.972
Rv0777purB0.972
Rv0357cpurA0.967
Rv2448cvalS0.959
Rv2448cvalS0.959
Rv2448cvalS0.959
Rv3275cpurE0.955
Rv0956purN0.954
Rv2139pyrD0.954
Rv1017cprsA0.95
Rv1017cprsA0.95
Rv1599hisD0.948
Rv0189cilvD0.947
Rv1603hisA0.946
Rv1536ileS0.944
Rv1536ileS0.944
Rv1112Rv11120.942
Rv1112Rv11120.942
Rv1021Rv10210.939
Rv0733adk0.932
Rv2225panB0.931
Rv2783cgpsI0.93
Rv2783cgpsI0.93
Rv2783cgpsI0.93
Rv2783cgpsI0.93
Rv2783cgpsI0.93
Rv2883cpyrH0.929
Rv3309cupp0.926
Rv0780purC0.926
Rv1384carB0.925
Rv1384carB0.925
Rv1384carB0.925
Rv1384carB0.925
Rv0440groEL20.921
Rv2438cnadE0.917
Rv2438cnadE0.917
Rv1601hisB0.914
Rv1383carA0.911
Rv1383carA0.911
Rv1010ksgA0.908
Rv2992cgltS0.906
Rv3708casd0.902
Rv3708casd0.902
Rv1437pgk0.902
Rv1652argC0.901
Rv1652argC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
xanthosine monophosphatePubChem0.994364.205
xanthosine 5'-phosphatePubChem0.991364.205
guanylatePubChem0.982363.221
adenosine monophosphatePubChem0.975347.221
pyrophosphatePubChem0.971177.975
inosine monophosphatePubChem0.964348.206
xanthosine-5'-phosphatePubChem0.94364.205
guanosine diphosphatePubChem0.925443.201
polyglutaminePubChem0.925146.145
NAD+PubChem0.922663.425
adenosine triphosphatePubChem0.902507.181
glutamatePubChem0.902147.129
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
glutaminPubChem0.9146.145
adenosine diphosphatePubChem0.9427.201
deuteriumPubChem0.92.01588
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
phosphatePubChem0.80896.9872
guaninePubChem0.772151.126
acivicinPubChem0.743178.574
magnesiumPubChem0.70824.305
selenomethioninePubChem0.706196.106
SeMetPubChem0.706196.106
citratePubChem0.7192.124
hydron; phosphonato phosphatePubChem0.7175.959
hydron diphosphatePubChem0.7391.981