SInCRe - Rv1603

Tuberculist information

Gene name	hisA
Protein function	Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1803.29
Molecular mass(da)	25730.9
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 245

	  		  	1    VMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGR   60
			  	61   GSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGE  120
			  	121  HGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGG  180
			  	181  PNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL  240
			  	241  AAVRD

Known structures in the PDB

	PDB ID	2Y85
	Total residue count	976
	Number of chains	4
	Method	X-RAY
	Resolution	2.4

	PDB ID	2Y88
	Total residue count	244
	Number of chains	1
	Method	X-RAY
	Resolution	1.33

	PDB ID	2Y89
	Total residue count	244
	Number of chains	1
	Method	X-RAY
	Resolution	2.5

	PDB ID	3ZS4
	Total residue count	244
	Number of chains	1
	Method	X-RAY
	Resolution	1.9

Number of amino acids : 245

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
His_biosynth	PF00977	4-234

Mtb Structural Proteome models

Model Number	1
Model name	Rv1603
Template	1VZW APDB CREDO
Template coverage	3_238
Template Identity(%)	70.1
Model coverage(%)	97.6
Normalized DOPE score	-1.219

Structure Models from Chopin

Model Number	1
Profile	c.1.2.1 - 3.20.20.70 Click for model details
zscore	42.33
Residue begin	1
Residue end	245

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1603	Gene name	Confidence Score
Rv1606	hisI	0.999
Rv1599	hisD	0.999
Rv1601	hisB	0.999
Rv1602	hisH	0.999
Rv1605	hisF	0.998
Rv2121c	hisG	0.998
Rv1600	hisC1	0.998
Rv2121c	hisG	0.998
Rv1611	trpC	0.997
Rv2192c	trpD	0.991
Rv2192c	trpD	0.991
Rv3772	hisC2	0.955
Rv0500	proC	0.952
Rv0500	proC	0.952
Rv3396c	guaA	0.946
Rv3396c	guaA	0.946
Rv3396c	guaA	0.946
Rv1612	trpB	0.938
Rv1609	trpE	0.935
Rv1609	trpE	0.935
Rv2122c	hisE	0.925
Rv0013	trpG	0.915

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
imidazole glycerol phosphatePubChem	0.904	238.135
PRFARPubChem	0.903	577.331
aminoimidazole carboxamide ribonucleotidePubChem	0.901	338.211
5-aminoimidazole-4-carboxamide ribosidePubChem	0.901	338.211
phosphoribosyl-AMPPubChem	0.9	559.316
polyglutaminePubChem	0.9	146.145
Chebi:17805PubChem	0.9	238.135
N-(5'-phosphoribosyl)anthranilatePubChem	0.9	349.23
phosphoribosyl-formimino-aicar-PPubChem	0.9	573.299
C04896PubChem	0.9	577.331
glutaminPubChem	0.9	146.145
C01302PubChem	0.9	349.23
phosphoribulosylformimino-AICAR-PPubChem	0.9	577.331
glutamatePubChem	0.9	147.129
N-(5-phospho-D-ribosyl)-AMPPubChem	0.9	559.316
deuteriumPubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
hydroxyl radicalsPubChem	0.9	17.0073
NSC292227PubChem	0.9	338.211
H(+)PubChem	0.9	2.01588
sulfatePubChem	0.711	96.0626