SInCRe - Rv3772

Tuberculist information

Gene name	hisC2
Protein function	Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	4217.13
Molecular mass(da)	38007.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 353

	  		  	1    VTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCV   60
			  	61   QLKAALARHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVA  120
			  	121  GAIPIQVPLTDHTFDLYAMLATVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAHIL  180
			  	181  IAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALD  240
			  	241  KVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVW  300
			  	301  LPLGSRTQDFVEQAADARIVVRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ

Known structures in the PDB

No Known structures

Number of amino acids : 353

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aminotran_1_2	PF00155	22-344

Mtb Structural Proteome models

Model Number	1
Model name	Rv3772
Template	1UU1 APDB CREDO
Template coverage	6_335
Template Identity(%)	30.0
Model coverage(%)	96.6
Normalized DOPE score	-0.493

Structure Models from Chopin

Model Number	1
Profile	c.67.1.1 Click for model details
zscore	22.86
Residue begin	1
Residue end	353

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3772	Gene name	Confidence Score
Rv1601	hisB	0.995
Rv3838c	pheA	0.99
Rv3838c	pheA	0.99
Rv3754	tyrA	0.987
Rv1599	hisD	0.981
Rv1606	hisI	0.977
Rv1605	hisF	0.971
Rv2121c	hisG	0.965
Rv2121c	hisG	0.965
Rv1602	hisH	0.96
Rv1603	hisA	0.955
Rv2192c	trpD	0.917
Rv2192c	trpD	0.917
Rv1611	trpC	0.913
Rv1383	carA	0.902
Rv1383	carA	0.902
Rv1908c	katG	0.901

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
histidinol phosphatePubChem	0.969	221.151
phosphatePubChem	0.943	96.9872
alpha-ketoglutaratePubChem	0.934	146.098
histidinol-phosphatePubChem	0.927	221.151
imidazole acetol phosphatePubChem	0.927	220.12
histidinolPubChem	0.914	141.171
glutamatePubChem	0.913	147.129
p-hydroxyphenylpyruvic acidPubChem	0.9	180.157
imidazole glycerol phosphatePubChem	0.9	238.135
phenylpyruvatePubChem	0.9	164.158
prephenatePubChem	0.9	226.183
L-histidinolPubChem	0.9	141.171
L-tyrosinePubChem	0.9	181.189
protiumPubChem	0.9	2.01576
hydroxyl radicalsPubChem	0.9	17.0073
carbon dioxidePubChem	0.9	44.0095
L-phenylalaninePubChem	0.9	165.189
H(+)PubChem	0.9	2.01588
deuteriumPubChem	0.9	2.01588
Chebi:17805PubChem	0.9	238.135
selenomethioninePubChem	0.784	196.106
SeMetPubChem	0.784	196.106
pyridoxal phosphatePubChem	0.747	247.142