Rv3754

Tuberculist information
Gene nametyrA
Protein functionPrephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4200.42
Molecular mass(da)30991.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 301
	  		  	1    MRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPG   60
			  	61   MLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFN  120
			  	121  RAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVT  180
			  	181  AAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQS  240
			  	241  HGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSP  300
			  	301  Q

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 3 to 249  |  Coverage: 81% PDH Range: 1 to 261  |  Coverage: 86% 1 Range: 154 to 272  |  Coverage: 39% 1
Number of amino acids : 301
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PDHPF021533-249
Mtb Structural Proteome models
Model Number1
Model nameRv3754
Template2G5C    APDBCREDO
Template coverage46_310
Template Identity(%)20.3
Model coverage(%)86.1
Normalized DOPE score0.734

Structure Models from Chopin
Model Number1
Profilea.100.1.12
Click for model details
zscore19.62
Residue begin154
Residue end272
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3754Gene nameConfidence Score
Rv3838cpheA0.999
Rv3838cpheA0.999
Rv2538caroB0.989
Rv3772hisC20.987
Rv1885cRv1885c0.983
Rv2537caroD0.983
Rv3227aroA0.981
Rv1600hisC10.973
Rv2540caroF0.972
Rv3709cask0.956
Rv3709cask0.956
Rv3709cask0.956
Rv1611trpC0.914
Rv2192ctrpD0.905
Rv2192ctrpD0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
prephenatePubChem0.985226.183
p-hydroxyphenylpyruvic acidPubChem0.978180.157
L-tyrosinePubChem0.764181.189
SeMetPubChem0.752196.106
selenomethioninePubChem0.752196.106
arogenatePubChem0.72227.214
NADPPubChem0.716744.413
L-arogenatePubChem0.71227.214