SInCRe - Rv1600

Tuberculist information

Gene name	hisC1
Protein function	Probable histidinol-phosphate aminotransferase HisC1
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1800.9
Molecular mass(da)	40581.1
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 380

	  		  	1    MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREA   60
			  	61   AIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSA  120
			  	121  IGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQ  180
			  	181  SVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGR  240
			  	241  LGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLN  300
			  	301  DMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLR  360
			  	361  ASARIATDLVPVTRSPVGAP

Known structures in the PDB

No Known structures

Number of amino acids : 380

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aminotran_1_2	PF00155	32-361

Mtb Structural Proteome models

Model Number	1
Model name	Rv1600
Template	1UU1 APDB CREDO
Template coverage	13_332
Template Identity(%)	32.2
Model coverage(%)	89.2
Normalized DOPE score	-0.095

Structure Models from Chopin

Model Number	1
Profile	c.67.1.1 Click for model details
zscore	23.14
Residue begin	1
Residue end	380

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1600	Gene name	Confidence Score
Rv1601	hisB	0.999
Rv1605	hisF	0.999
Rv1599	hisD	0.999
Rv1603	hisA	0.998
Rv1606	hisI	0.998
Rv2121c	hisG	0.997
Rv2121c	hisG	0.997
Rv1602	hisH	0.996
Rv3838c	pheA	0.985
Rv3838c	pheA	0.985
Rv1611	trpC	0.983
Rv3754	tyrA	0.973
Rv1908c	katG	0.911
Rv2192c	trpD	0.908
Rv2192c	trpD	0.908

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
histidinol phosphatePubChem	0.985	221.151
phosphatePubChem	0.975	96.9872
alpha-ketoglutaratePubChem	0.95	146.098
imidazole acetol phosphatePubChem	0.942	220.12
histidinol-phosphatePubChem	0.941	221.151
histidinolPubChem	0.935	141.171
glutamatePubChem	0.919	147.129
carbon dioxidePubChem	0.9	44.0095
L-phenylalaninePubChem	0.9	165.189
H(+)PubChem	0.9	2.01588
deuteriumPubChem	0.9	2.01588
Chebi:17805PubChem	0.9	238.135
L-tyrosinePubChem	0.9	181.189
p-hydroxyphenylpyruvic acidPubChem	0.9	180.157
imidazole glycerol phosphatePubChem	0.9	238.135
phenylpyruvatePubChem	0.9	164.158
prephenatePubChem	0.9	226.183
L-histidinolPubChem	0.9	141.171
protiumPubChem	0.9	2.01576
hydroxyl radicalsPubChem	0.9	17.0073
pyridoxamine 5'-phosphatePubChem	0.839	248.173
pyridoxal phosphatePubChem	0.828	247.142
selenomethioninePubChem	0.751	196.106
SeMetPubChem	0.751	196.106