Rv1606

Tuberculist information
Gene namehisI
Protein functionProbable phosphoribosyl-AMP 1,6 cyclohydrolase HisI
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1805.65
Molecular mass(da)12464.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 115
	  		  	1    MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE   60
			  	61   QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD

Known structures in the PDB
No Known structures
1 12 23 34 45 56 67 78 89 100 111 Range: 33 to 107  |  Coverage: 64% PRA-CH Range: 3 to 115  |  Coverage: 97% 1 Range: 1 to 115  |  Coverage: 99% 1
Number of amino acids : 115
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PRA-CHPF0150233-107
Mtb Structural Proteome models
Model Number1
Model nameRv1606
Template1ZPS    APDBCREDO
Template coverage8_118
Template Identity(%)50.5
Model coverage(%)97.4
Normalized DOPE score-0.662

Structure Models from Chopin
Model Number1
Profileb.168.1.1
Click for model details
zscore31.85
Residue begin1
Residue end115
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1606Gene nameConfidence Score
Rv1605hisF0.999
Rv1599hisD0.999
Rv1601hisB0.999
Rv1603hisA0.999
Rv1600hisC10.998
Rv1602hisH0.998
Rv2122chisE0.996
Rv2121chisG0.992
Rv2121chisG0.992
Rv3772hisC20.977
Rv1609trpE0.969
Rv1609trpE0.969
Rv1611trpC0.962
Rv2580chisS0.949
Rv2580chisS0.949
Rv2192ctrpD0.945
Rv2192ctrpD0.945
Rv0013trpG0.94
Rv2614cthrS0.938
Rv2614cthrS0.938
Rv2614cthrS0.938
Rv0382cpyrE0.92
Rv1612trpB0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphoribosyl-AMPPubChem0.992559.316
phosphoribosyl-ATPPubChem0.991719.276
pyrophosphatePubChem0.974177.975
deuteriumPubChem0.92.01588
phosphoribulosylformimino-AICAR-PPubChem0.9577.331
C04896PubChem0.9577.331
protiumPubChem0.92.01576
phosphoribosyl-formimino-aicar-PPubChem0.9573.299
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
N-(5-phospho-D-ribosyl)-AMPPubChem0.9559.316
PRFARPubChem0.9577.331
5-phosphoribosyl-ATPPubChem0.9714.236
cadmiumPubChem0.81232.515
acetatePubChem0.70959.044
hydride acetatePubChem0.70961.0599