Rv1609

Tuberculist information
Gene nametrpE
Protein functionAnthranilate synthase component I TrpE (glutamine amidotransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1807.9
Molecular mass(da)55816.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 516
	  		  	1    VHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENG   60
			  	61   RSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEP  120
			  	121  GLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAAVDHHEGTITLIAN  180
			  	181  AVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIV  240
			  	241  EYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFS  300
			  	301  IVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGR  360
			  	361  NDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEGRTALDAVTACFPAGTLSGAP  420
			  	421  KVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADS  480
			  	481  NGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 33 to 177  |  Coverage: 27% Anth_synt_I_N Range: 232 to 492  |  Coverage: 50% Chorismate_bind Range: 24 to 506  |  Coverage: 93% 1 Range: 7 to 510  |  Coverage: 97% 1
Number of amino acids : 516
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Anth_synt_I_NPF0471533-177
Chorismate_bindPF00425232-492
Mtb Structural Proteome models
Model Number1
Model nameRv1609
Template1I7Q    APDBCREDO
Template coverage8_516
Template Identity(%)38.5
Model coverage(%)93.4
Normalized DOPE score-0.491

Structure Models from Chopin
Model Number1
Profiled.161.1.1 - 3.60.120.10
Click for model details
zscore71.09
Residue begin7
Residue end510
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1609Gene nameConfidence Score
Rv0013trpG0.999
Rv2192ctrpD0.999
Rv1611trpC0.999
Rv2192ctrpD0.999
Rv1612trpB0.997
Rv2540caroF0.995
Rv1613trpA0.994
Rv1605hisF0.99
Rv1606hisI0.969
Rv1602hisH0.954
Rv1601hisB0.951
Rv1599hisD0.947
Rv1885cRv1885c0.945
Rv3336ctrpS0.943
Rv2538caroB0.936
Rv1603hisA0.935
Rv2121chisG0.934
Rv2121chisG0.934
Rv3838cpheA0.932
Rv3838cpheA0.932
Rv1408rpe0.908
Rv2386cmbtI0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
chorismatePubChem0.991226.183
anthranilic acidPubChem0.987137.136
phosphatePubChem0.93496.9872
glutamatePubChem0.927147.129
phosphoribosylpyrophosphatePubChem0.925390.07
N-(5'-phosphoribosyl)-anthranilatePubChem0.923346.207
N-(5'-phosphoribosyl)anthranilatePubChem0.922349.23
polyglutaminePubChem0.914146.145
pyruvic acidPubChem0.90988.0621
L-tryptophanPubChem0.906204.225
pyrophosphatePubChem0.905177.975
glutaminPubChem0.9146.145
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
5-enolpyruvylshikimate-3-phosphatePubChem0.9324.178
H(+)PubChem0.92.01588
mycobactin TPubChem0.809872.142
isochorismatePubChem0.776226.183
mycobactinPubChem0.722591.61
5-methyltryptophanPubChem0.719218.252