SInCRe - Rv2192c

Tuberculist information

Gene name	trpD
Protein function	Probable anthranilate phosphoribosyltransferase TrpD
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2455.63
Molecular mass(da)	37707.8
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 370

	  		  	1    VALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPA   60
			  	61   QIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLST  120
			  	121  MAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAP  180
			  	181  RFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSS  240
			  	241  VLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAA  300
			  	301  VRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLL  360
			  	361  ARWVRFGRQI

Known structures in the PDB

	PDB ID	1ZVW
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	2.3

	PDB ID	2BPQ
	Total residue count	746
	Number of chains	2
	Method	X-RAY
	Resolution	1.9

	PDB ID	3QQS
	Total residue count	1508
	Number of chains	4
	Method	X-RAY
	Resolution	1.97

	PDB ID	3QR9
	Total residue count	754
	Number of chains	2
	Method	X-RAY
	Resolution	1.87

	PDB ID	3QS8
	Total residue count	1508
	Number of chains	4
	Method	X-RAY
	Resolution	2

	PDB ID	3QSA
	Total residue count	754
	Number of chains	2
	Method	X-RAY
	Resolution	2.18

	PDB ID	3R6C
	Total residue count	754
	Number of chains	2
	Method	X-RAY
	Resolution	1.83

	PDB ID	3R88
	Total residue count	754
	Number of chains	2
	Method	X-RAY
	Resolution	1.73

	PDB ID	3TWP
	Total residue count	1508
	Number of chains	4
	Method	X-RAY
	Resolution	1.83

	PDB ID	3UU1
	Total residue count	1508
	Number of chains	4
	Method	X-RAY
	Resolution	1.82

	PDB ID	4GIU
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.67

	PDB ID	4GKM
	Total residue count	758
	Number of chains	2
	Method	X-RAY
	Resolution	1.67

	PDB ID	4IJ1
	Total residue count	760
	Number of chains	2
	Method	X-RAY
	Resolution	1.79

	PDB ID	4M0R
	Total residue count	758
	Number of chains	2
	Method	X-RAY
	Resolution	1.96

	PDB ID	4N5V
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.9

	PDB ID	4N8Q
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	2.08

	PDB ID	4N93
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	2.03

	PDB ID	4OWM
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.99

	PDB ID	4OWN
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	2.11

	PDB ID	4OWO
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.99

	PDB ID	4OWQ
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.89

	PDB ID	4OWS
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	2.43

	PDB ID	4OWU
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.89

	PDB ID	4OWV
	Total residue count	756
	Number of chains	2
	Method	X-RAY
	Resolution	1.9

Number of amino acids : 370

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Glycos_trans_3N	PF02885	26-91
Glycos_transf_3	PF00591	99-357

Mtb Structural Proteome models

Model Number	1
Model name	Rv2192c_2bpq_A
Template	2BPQ APDB CREDO
Template coverage	25_369
Template Identity(%)	100.0
Model coverage(%)	93.0
Normalized DOPE score	-1.66

Model Number	2
Model name	Rv2192c
Template	2BPQ APDB CREDO
Template coverage	25_369
Template Identity(%)	100.0
Model coverage(%)	93.0
Normalized DOPE score	-1.431

Structure Models from Chopin

Model Number	1
Profile	a.46.2.1, c.27.1.1 - 1.20.970.10, 3.40.1030.10 Click for model details
zscore	66.88
Residue begin	25
Residue end	370

Model Number	2
Profile	3.40.1030.10 Click for model details
zscore	42.45
Residue begin	90
Residue end	370

Model Number	3
Profile	a.46.2.1 Click for model details
zscore	17.05
Residue begin	24
Residue end	95

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2192c	Gene name	Confidence Score
Rv0013	trpG	0.999
Rv1609	trpE	0.999
Rv1609	trpE	0.999
Rv1611	trpC	0.999
Rv1612	trpB	0.998
Rv1613	trpA	0.994
Rv2386c	mbtI	0.992
Rv1603	hisA	0.991
Rv2540c	aroF	0.976
Rv1408	rpe	0.967
Rv1605	hisF	0.965
Rv1599	hisD	0.964
Rv1005c	pabB	0.956
Rv3838c	pheA	0.953
Rv3838c	pheA	0.953
Rv1293	lysA	0.945
Rv1293	lysA	0.945
Rv3227	aroA	0.945
Rv1606	hisI	0.945
Rv2538c	aroB	0.945
Rv3455c	truA	0.94
Rv3336c	trpS	0.936
Rv1602	hisH	0.934
Rv3602c	panC	0.922
Rv2445c	ndkA	0.92
Rv3772	hisC2	0.917
Rv2121c	hisG	0.912
Rv2121c	hisG	0.912
Rv1600	hisC1	0.908
Rv1601	hisB	0.908
Rv3754	tyrA	0.905
Rv1017c	prsA	0.902
Rv1017c	prsA	0.902
Rv1023	eno	0.901
Rv1023	eno	0.901

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
phosphoribosylpyrophosphatePubChem	0.999	390.07
anthranilic acidPubChem	0.995	137.136
pyrophosphatePubChem	0.985	177.975
glycerolPubChem	0.978	92.0938
magnesiumPubChem	0.977	24.305
N-(5'-phosphoribosyl)-anthranilatePubChem	0.957	346.207
N-(5'-phosphoribosyl)anthranilatePubChem	0.957	349.23
benzamidinePubChem	0.939	120.152
selenomethioninePubChem	0.937	196.106
chorismatePubChem	0.937	226.183
SeMetPubChem	0.937	196.106
glutamatePubChem	0.912	147.129
C01302PubChem	0.9	349.23
1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-PPubChem	0.9	349.23
H(+)PubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
glutaminPubChem	0.9	146.145
pyruvic acidPubChem	0.9	88.0621
polyglutaminePubChem	0.9	146.145
deuteriumPubChem	0.9	2.01588
manganesePubChem	0.757	54.938
L-tryptophanPubChem	0.74	204.225
Tn5PubChem	0.716	270.111