Rv1005c

Tuberculist information
Gene namepabB
Protein functionProbable para-aminobenzoate synthase component I PABD
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1122.22
Molecular mass(da)47880.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 458
	  		  	1    LNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPAVLRAVGRATSRLDLPP   60
			  	61   PAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPDATGAVGGGWVGYLSYPDAGA  120
			  	121  DGRPHRIPEAAGGWTDCVLRRDRDGQWWYESLSGAPIADWLASALATTRASVARPAPACR  180
			  	181  IDWEPADRAAHRDGVLACLEAIGAGEVYQACVCTQFAGTVTGSPLDFFIDGFGRTAPSRS  240
			  	241  AFVAGPWGAVASLSPELFLRRRGSVVTSSPIKGTLPLDAPPSALRASAKEVAENIMIVDL  300
			  	301  VRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVSTVSARVPLEEPMSALLDAAFPPASVTG  360
			  	361  TPKLRARQLISQWERYRRGIYCGTVGLASPVAGCELNVAIRTVEFDTAGNAVLGVGGGIT  420
			  	421  ADSDPDAEWAECLHKAAPIVGLPAATRTTPARLASKVR

Known structures in the PDB
No Known structures
1 46 91 136 181 226 271 316 361 406 451 Range: 187 to 435  |  Coverage: 54% Chorismate_bind Range: 6 to 444  |  Coverage: 95% 1 Range: 1 to 453  |  Coverage: 98% 1
Number of amino acids : 458
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Chorismate_bindPF00425187-435
Mtb Structural Proteome models
Model Number1
Model nameRv1005c
Template1K0E    APDBCREDO
Template coverage10_452
Template Identity(%)30.8
Model coverage(%)95.6
Normalized DOPE score0

Structure Models from Chopin
Model Number1
Profiled.161.1.1 - 3.60.120.10
Click for model details
zscore49.89
Residue begin1
Residue end453
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1005cGene nameConfidence Score
Rv0013trpG0.999
Rv0812Rv08120.956
Rv2192ctrpD0.956
Rv2192ctrpD0.956
Rv2540caroF0.949
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
chorismatePubChem0.964226.183
p-aminobenzoic acidPubChem0.935137.136
phosphatePubChem0.92596.9872
4-amino-4-deoxychorismatePubChem0.924225.198
glutamatePubChem0.911147.129
polyglutaminePubChem0.901146.145
H(+)PubChem0.92.01588
(3R)-4-ammonio-3-(1-carboxylatovinyloxy)cyclohexa-1,5-diene-1-carboxylatePubChem0.9224.19
pyruvic acidPubChem0.988.0621
glutaminPubChem0.9146.145
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
5-enolpyruvylshikimate-3-phosphatePubChem0.9324.178
mycobactin TPubChem0.713872.142