Rv0812

Tuberculist information
Gene nameRv0812
Protein functionProbable amino acid aminotransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)906.423
Molecular mass(da)31090.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 289
	  		  	1    VVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDL   60
			  	61   PEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGAR  120
			  	121  RDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYV  180
			  	181  LEGPRSTVVIATDGDQGGGNPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVA  240
			  	241  DLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 42 to 283  |  Coverage: 83% Aminotran_4 Range: 2 to 283  |  Coverage: 97% 1 Range: 1 to 289  |  Coverage: 99% 1 Range: 121 to 289  |  Coverage: 58% 2
Number of amino acids : 289
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_4PF0106342-283
Mtb Structural Proteome models
Model Number1
Model nameRv0812
Template1IYE    APDBCREDO
Template coverage7_287
Template Identity(%)19.9
Model coverage(%)96.9
Normalized DOPE score-0.222

Structure Models from Chopin
Model Number1
Profilee.17.1.1
Click for model details
zscore34.58
Residue begin1
Residue end289
Model Number2
Profile3.20.10.10
Click for model details
zscore14.01
Residue begin121
Residue end289
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0812Gene nameConfidence Score
Rv1005cpabB0.956
Rv0013trpG0.952
Rv3608cfolP10.917
Rv1207folP20.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyruvic acidPubChem0.988.0621
chorismatePubChem0.9226.183
7,8-dihydropterin pyrophosphatePubChem0.9355.138
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
(3R)-4-ammonio-3-(1-carboxylatovinyloxy)cyclohexa-1,5-diene-1-carboxylatePubChem0.9224.19
pyrophosphatePubChem0.9177.975
dihydropteroatePubChem0.9314.299
glutamatePubChem0.9147.129
glutaminPubChem0.9146.145
polyglutaminePubChem0.9146.145
protiumPubChem0.92.01576
p-aminobenzoic acidPubChem0.9137.136
4-amino-4-deoxychorismatePubChem0.9225.198