Rv3838c

Tuberculist information
Gene namepheA
Protein functionPrephenate dehydratase PheA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4311.7
Molecular mass(da)33601.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 321
	  		  	1    VVRIAYLGPEGTFTEAALVRMVAAGLVPETGPDALQRMPVESAPAALAAVRDGGADYACV   60
			  	61   PIENSIDGSVLPTLDSLAIGVRLQVFAETTLDVTFSIVVKPGRNAADVRTLAAFPVAAAQ  120
			  	121  VRQWLAAHLPAADLRPAYSNADAARQVADGLVDAAVTSPLAAARWGLAALADGVVDESNA  180
			  	181  RTRFVLVGRPGPPPARTGADRTSAVLRIDNQPGALVAALAEFGIRGIDLTRIESRPTRTE  240
			  	241  LGTYLFFVDCVGHIDDEAVAEALKAVHRRCADVRYLGSWPTGPAAGAQPPLVDEASRWLA  300
			  	301  RLRAGKPEQTLVRPDDQGAQA

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 4 to 192  |  Coverage: 58% PDT Range: 202 to 268  |  Coverage: 20% ACT Range: 195 to 315  |  Coverage: 37% 1 Range: 202 to 280  |  Coverage: 24% 1
Number of amino acids : 321
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PDTPF008004-192
ACTPF01842202-268
Mtb Structural Proteome models
Model Number1
Model nameRv3838c
Template1PHZ    APDBCREDO
Template coverage28_148
Template Identity(%)20.9
Model coverage(%)37.4
Normalized DOPE score-0.157

Structure Models from Chopin
Model Number1
Profiled.58.18.3
Click for model details
zscore22.51
Residue begin202
Residue end280
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3838cGene nameConfidence Score
Rv3754tyrA0.999
Rv2540caroF0.997
Rv3772hisC20.99
Rv1885cRv1885c0.986
Rv1600hisC10.985
Rv2538caroB0.983
Rv2539caroK0.978
Rv2537caroD0.972
Rv1611trpC0.968
Rv2192ctrpD0.953
Rv2192ctrpD0.953
Rv3227aroA0.948
Rv2121chisG0.946
Rv2121chisG0.946
Rv1612trpB0.934
Rv1293lysA0.933
Rv1293lysA0.933
Rv1609trpE0.932
Rv1609trpE0.932
Rv3001cilvC0.929
Rv3001cilvC0.929
Rv1295thrC0.928
Rv2552caroE0.919
Rv2552caroE0.919
Rv2440cobg0.917
Rv2440cobg0.917
Rv2440cobg0.917
Rv1602hisH0.914
Rv1437pgk0.911
Rv0189cilvD0.909
Rv2996cserA10.904
Rv2996cserA10.904
Rv2996cserA10.904
Rv1908ckatG0.904
Rv3002cilvN0.903
Rv3002cilvN0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-phenylalaninePubChem0.995165.189
phenylpyruvatePubChem0.991164.158
prephenatePubChem0.989226.183
chorismatePubChem0.982226.183
p-hydroxyphenylpyruvic acidPubChem0.933180.157
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
carbon dioxidePubChem0.944.0095
protiumPubChem0.92.01576
glutamatePubChem0.9147.129
NAD+PubChem0.9663.425
5-enolpyruvylshikimate-3-phosphatePubChem0.9324.178
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
phosphatePubChem0.996.9872
deuteriumPubChem0.92.01588
alpha-ketoglutaratePubChem0.9146.098
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
selenomethioninePubChem0.793196.106
SeMetPubChem0.793196.106
polyethylene glycolPubChem0.77862.0678
arogenatePubChem0.756227.214
ethylene glycol; hydronPubChem0.72563.0758
acetatePubChem0.72559.044
hydride acetatePubChem0.72561.0599
L-tyrosinePubChem0.71181.189