Tuberculist information
Gene namearoE
Protein functionProbable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2871.21
Molecular mass(da)27208.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 269
	  		  	1    MSEGPKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWV   60
			  	61   GVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAGHA  120
			  	121  LVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLAD  180
			  	181  AVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQML  240
			  	241  LHQAFAQVEQFTGLPAPREAMTCALAALD
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Shikimate_dh_NPF0850110-92
Shikimate_DHPF01488112-208
Mtb Structural Proteome models
Model Number1
Model nameRv2552c
Template2D5C    APDBCREDO
Template coverage6_261
Template Identity(%)33.2
Model coverage(%)95.9
Normalized DOPE score0.095

Structure Models from Chopin
Model Number1
Profilec.2.1.7, c.58.1.5 - 3.40.192.10, 3.40.50.720
Click for model details
zscore49.61
Residue begin1
Residue end269
Model Number2
Profilec.58.1.5
Click for model details
zscore25.21
Residue begin1
Residue end104
Model Number3
Profile3.40.192.10
Click for model details
zscore10.8
Residue begin1
Residue end151
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2552cGene nameConfidence Score
Rv2539caroK0.999
Rv3227aroA0.999
Rv2538caroB0.999
Rv2537caroD0.996
Rv2540caroF0.994
Rv1389gmk0.967
Rv2981cddlA0.961
Rv2981cddlA0.961
Rv2553cRv2553c0.921
Rv3838cpheA0.919
Rv3838cpheA0.919
Rv1383carA0.905
Rv1383carA0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.996744.413
shikimic acidPubChem0.993174.151
3-dehydroshikimatePubChem0.976172.135
3-dehydroquinatePubChem0.953190.151
NADP(H)PubChem0.929745.421
H(+)PubChem0.9252.01588
deuteriumPubChem0.9242.01588
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
adenosine triphosphatePubChem0.9507.181
shikimate 3-phosphatePubChem0.9254.131
adenosine diphosphatePubChem0.9427.201
sulfatePubChem0.74996.0626
hydron sulfatePubChem0.749196.157
chorismatePubChem0.747226.183
NAD+PubChem0.706663.425