Rv3455c

Tuberculist information
Gene nametruA
Protein functionProbable tRNA pseudouridine synthase a TruA (pseudouridylate synthase I) (pseudouridine synthase I) (uracil hydrolyase)
Functional category(tuberculist)information pathways
Gene location(kb)3876.05
Molecular mass(da)28059.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 256
	  		  	1    VGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVDVPADALPNAYPRAGHV   60
			  	61   GDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRHYVYRLSTAPYGVEPQQAR  120
			  	121  YITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTIRDLQRLDWSRAGTLVTAHVT  180
			  	181  ADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGRSSDFAVAPAHGLTLIQVDYPPD  240
			  	241  DQLASRNLVTRDVRSG

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 3 to 97  |  Coverage: 36% PseudoU_synth_1 Range: 137 to 238  |  Coverage: 39% PseudoU_synth_1 Range: 4 to 238  |  Coverage: 91% 1 Range: 1 to 255  |  Coverage: 99% 1 Range: 99 to 240  |  Coverage: 55% 2 Range: 1 to 98  |  Coverage: 37% 3
Number of amino acids : 256
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PseudoU_synth_1PF014163-97
PseudoU_synth_1PF01416137-238
Mtb Structural Proteome models
Model Number1
Model nameRv3455c
Template1DJ0    APDBCREDO
Template coverage33_253
Template Identity(%)36.2
Model coverage(%)91.4
Normalized DOPE score0.224

Structure Models from Chopin
Model Number1
Profiled.265.1.1
Click for model details
zscore45.87
Residue begin1
Residue end255
Model Number2
Profile3.30.70.660
Click for model details
zscore30.31
Residue begin99
Residue end240
Model Number3
Profile3.30.70.580
Click for model details
zscore15
Residue begin1
Residue end98
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3455cGene nameConfidence Score
Rv3456crplQ0.989
Rv2988cleuC0.986
Rv3457crpoA0.985
Rv3457crpoA0.985
Rv3457crpoA0.985
Rv2793ctruB0.981
Rv2793ctruB0.981
Rv2447cfolC0.979
Rv2447cfolC0.979
Rv1540Rv15400.971
Rv1540Rv15400.971
Rv3014cligA0.968
Rv3014cligA0.968
Rv3014cligA0.968
Rv3014cligA0.968
Rv3459crpsK0.968
Rv3014cligA0.968
Rv3458crpsD0.955
Rv3442crpsI0.955
Rv3458crpsD0.955
Rv1612trpB0.954
Rv3460crpsM0.953
Rv3443crplM0.952
Rv0732secY0.951
Rv0700rpsJ0.947
Rv0719rplF0.943
Rv2192ctrpD0.94
Rv2192ctrpD0.94
Rv0710rpsQ0.936
Rv0716rplE0.934
Rv0716rplE0.934
Rv0708rplP0.934
Rv0720rplR0.933
Rv0808purF0.928
Rv0808purF0.928
Rv1406fmt0.926
Rv1406fmt0.926
Rv0705rpsS0.925
Rv0701rplC0.925
Rv2906ctrmD0.924
Rv0702rplD0.924
Rv0718rpsH0.919
Rv1711Rv17110.918
Rv1711Rv17110.918
Rv3708casd0.913
Rv0714rplN0.913
Rv3708casd0.913
Rv2995cleuB0.911
Rv0422cthiD0.91
Rv0723rplO0.909
Rv0703rplW0.909
Rv3240csecA10.908
Rv3240csecA10.908
Rv0707rpsC0.908
Rv0707rpsC0.908
Rv3240csecA10.908
Rv2580chisS0.903
Rv0683rpsG0.903
Rv2580chisS0.903
Rv1017cprsA0.902
Rv0704rplB0.902
Rv0704rplB0.902
Rv1017cprsA0.902
Rv1010ksgA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
uracilPubChem0.936112.087
D-ribose 5-phosphatePubChem0.9230.11
pseudouridine 5'-phosphatePubChem0.9324.181
pseudouridylic acidPubChem0.9324.181
hydroxyl radicalsPubChem0.917.0073
pseudouridinePubChem0.764244.201