Rv0732

Tuberculist information
Gene namesecY
Protein functionProbable preprotein translocase SecY
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)824.8
Molecular mass(da)47579.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 441
	  		  	1    VLSAFISSLRTVDLRRKILFTLGIVILYRVGAALPSPGVNFPNVQQCIKEASAGEAGQIY   60
			  	61   SLINLFSGGALLKLTVFAVGVMPYITASIIVQLLTVVIPRFEELRKEGQAGQSKMTQYTR  120
			  	121  YLAIALAILQATSIVALAANGGLLQGCSLDIIADQSIFTLVVIVLVMTGGAALVMWMGEL  180
			  	181  ITERGIGNGMSLLIFVGIAARIPAEGQSILESRGGVVFTAVCAAALIIIVGVVFVEQGQR  240
			  	241  RIPVQYAKRMVGRRMYGGTSTYLPLKVNQAGVIPVIFASSLIYIPHLITQLIRSGSGVVG  300
			  	301  NSWWDKFVGTYLSDPSNLVYIGIYFGLIIFFTYFYVSITFNPDERADEMKKFGGFIPGIR  360
			  	361  PGRPTADYLRYVLSRITLPGSIYLGVIAVLPNLFLQIGAGGTVQNLPFGGTAVLIMIGVG  420
			  	421  LDTVKQIESQLMQRNYEGFLK

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 75 to 425  |  Coverage: 79% SecY Range: 9 to 419  |  Coverage: 92% 1 Range: to   |  Coverage: 0% 1
Number of amino acids : 441
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SecYPF0034475-425
Mtb Structural Proteome models
Model Number1
Model nameRv0732
Template1RH5    APDBCREDO
Template coverage18_410
Template Identity(%)24.7
Model coverage(%)93.0
Normalized DOPE score0.736

Structure Models from Chopin
Model Number1
Profilef.41.1.1 - 1.10.3370.10
Click for model details
zscore47.03
Residue begin
Residue end
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0732Gene nameConfidence Score
Rv3240csecA10.999
Rv3240csecA10.999
Rv3240csecA10.999
Rv0733adk0.998
Rv0734mapA0.998
Rv1821secA20.997
Rv3457crpoA0.997
Rv2586csecF0.997
Rv3457crpoA0.997
Rv1821secA20.997
Rv2586csecF0.997
Rv3457crpoA0.997
Rv1821secA20.997
Rv2587csecD0.996
Rv2587csecD0.996
Rv0706rplV0.993
Rv0716rplE0.993
Rv0716rplE0.993
Rv0668rpoC0.992
Rv0668rpoC0.992
Rv0668rpoC0.992
Rv0668rpoC0.992
Rv0638secE10.992
Rv0668rpoC0.992
Rv0667rpoB0.991
Rv0710rpsQ0.991
Rv0719rplF0.991
Rv0700rpsJ0.991
Rv0667rpoB0.991
Rv0720rplR0.991
Rv0667rpoB0.991
Rv0715rplX0.991
Rv0707rpsC0.991
Rv0702rplD0.991
Rv0667rpoB0.991
Rv0707rpsC0.991
Rv0703rplW0.991
Rv0667rpoB0.991
Rv0708rplP0.991
Rv0667rpoB0.991
Rv0723rplO0.991
Rv0718rpsH0.99
Rv3458crpsD0.99
Rv0705rpsS0.99
Rv3458crpsD0.99
Rv0714rplN0.99
Rv3459crpsK0.99
Rv0701rplC0.99
Rv3456crplQ0.99
Rv0721rpsE0.99
Rv3460crpsM0.99
Rv0721rpsE0.99
Rv0639nusG0.99
Rv0704rplB0.99
Rv0639nusG0.99
Rv0704rplB0.99
Rv0682rpsL0.988
Rv2861cmapB0.988
Rv0684fusA10.986
Rv0684fusA10.986
Rv0684fusA10.986
Rv0684fusA10.986
Rv0684fusA10.986
Rv0683rpsG0.985
Rv3443crplM0.984
Rv2921cftsY0.984
Rv2921cftsY0.984
Rv0717rpsN10.984
Rv0685tuf0.983
Rv0685tuf0.983
Rv0685tuf0.983
Rv0640rplK0.982
Rv0640rplK0.982
Rv0722rpmD0.982
Rv2056crpsN20.98
Rv3846sodA0.978
Rv3846sodA0.978
Rv2916cffh0.978
Rv2916cffh0.978
Rv2916cffh0.978
Rv0652rplL0.968
Rv2839cinfB0.967
Rv2839cinfB0.967
Rv2839cinfB0.967
Rv2839cinfB0.967
Rv3462cinfA0.966
Rv3442crpsI0.962
Rv0641rplA0.958
Rv2462ctig0.954
Rv2462ctig0.954
Rv2462ctig0.954
Rv3455ctruA0.951
Rv2889ctsf0.95
Rv2889ctsf0.95
Rv2906ctrmD0.949
Rv0709rpmC0.946
Rv1308atpA0.936
Rv1308atpA0.936
Rv1308atpA0.936
Rv2783cgpsI0.935
Rv2783cgpsI0.935
Rv2783cgpsI0.935
Rv2783cgpsI0.935
Rv2783cgpsI0.935
Rv3610cftsH0.933
Rv3610cftsH0.933
Rv3610cftsH0.933
Rv0651rplJ0.931
Rv1440secG0.927
Rv2442crplU0.922
Rv1641infC0.919
Rv1641infC0.919
Rv1023eno0.912
Rv1023eno0.912
Rv0056rplI0.911
Rv0056rplI0.911
Rv2572caspS0.908
Rv2572caspS0.908
Rv2572caspS0.908
Rv2093ctatC0.907
Rv0350dnaK0.904
Rv2907crimM0.903
Rv2907crimM0.903
Rv1630rpsA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.72965.409
beryllium fluoridePubChem0.70447.009
adenosine diphosphatePubChem0.704427.201
magnesiumPubChem0.70424.305