Rv1308

Tuberculist information
Gene nameatpA
Protein functionProbable ATP synthase alpha chain AtpA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1463.23
Molecular mass(da)59288.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 549
	  		  	1    MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPG   60
			  	61   GILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPVGDGFLGRVVNPLGQPIDG  120
			  	121  RGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTA  180
			  	181  VCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAAVRRTLEEGGAMDYTTIVAAAAS  240
			  	241  ESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTKQAEAYRAISLLLRRPPGREAYPGD  300
			  	301  VFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLF  360
			  	361  NQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDAASKAQ  420
			  	421  LERGARLVELLKQPQSQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASEE  480
			  	481  EILTEIRDSQKLTEEAADKLTEVIKNFKKGFAATGGGSVVPDEHVEALDEDKLAKEAVKV  540
			  	541  KKPAPKKKK

Known structures in the PDB
No Known structures
1 55 109 163 217 271 325 379 433 487 541 Range: 27 to 95  |  Coverage: 12% ATP-synt_ab_N Range: 151 to 375  |  Coverage: 40% ATP-synt_ab Range: 387 to 509  |  Coverage: 22% ATP-synt_ab_C Range: 24 to 515  |  Coverage: 89% 1 Range: 23 to 514  |  Coverage: 89% 1 Range: 382 to 513  |  Coverage: 23% 2 Range: 27 to 95  |  Coverage: 12% 3
Number of amino acids : 549
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP-synt_ab_NPF0287427-95
ATP-synt_abPF00006151-375
ATP-synt_ab_CPF00306387-509
Mtb Structural Proteome models
Model Number1
Model nameRv1308
Template1SKY    BPDBCREDO
Template coverage21_502
Template Identity(%)59.9
Model coverage(%)89.4
Normalized DOPE score-0.522

Structure Models from Chopin
Model Number1
Profilea.69.1.1, b.49.1.1, c.37.1.11 - 1.20.150.20, 2.40.30.20, 3.40.50.300
Click for model details
zscore80.55
Residue begin23
Residue end514
Model Number2
Profile1.20.150.20
Click for model details
zscore28.19
Residue begin382
Residue end513
Model Number3
Profileb.49.1.1
Click for model details
zscore13.44
Residue begin27
Residue end95
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1308Gene nameConfidence Score
Rv1309atpG0.999
Rv1310atpD0.999
Rv1304atpB0.999
Rv1310atpD0.999
Rv1305atpE0.999
Rv1310atpD0.999
Rv1306atpF0.999
Rv1311atpC0.999
Rv1307atpH0.996
Rv1307atpH0.996
Rv3628ppa0.987
Rv0733adk0.984
Rv3148nuoD0.976
Rv3457crpoA0.973
Rv3457crpoA0.973
Rv3457crpoA0.973
Rv1248cRv1248c0.969
Rv1248cRv1248c0.969
Rv1248cRv1248c0.969
Rv2889ctsf0.962
Rv2889ctsf0.962
Rv1023eno0.962
Rv1023eno0.962
Rv0685tuf0.96
Rv0685tuf0.96
Rv0685tuf0.96
Rv0952sucD0.954
Rv0952sucD0.954
Rv0951sucC0.952
Rv0951sucC0.952
Rv2441crpmA0.95
Rv3456crplQ0.946
Rv2299chtpG0.938
Rv2299chtpG0.938
Rv0732secY0.936
Rv0705rpsS0.936
Rv3459crpsK0.935
Rv0641rplA0.935
Rv1098cfum0.935
Rv1098cfum0.935
Rv0701rplC0.934
Rv0708rplP0.933
Rv3150nuoF0.932
Rv3150nuoF0.932
Rv3150nuoF0.932
Rv0716rplE0.931
Rv0716rplE0.931
Rv3028cfixB0.924
Rv3028cfixB0.924
Rv0053rpsF0.923
Rv0718rpsH0.923
Rv0719rplF0.922
Rv0700rpsJ0.922
Rv3152nuoH0.922
Rv3043cctaD0.922
Rv3153nuoI0.921
Rv2883cpyrH0.914
Rv0896gltA20.914
Rv3442crpsI0.914
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0707rpsC0.907
Rv0707rpsC0.907
Rv0720rplR0.906
Rv3149nuoE0.905
Rv3151nuoG0.904
Rv3151nuoG0.904
Rv2440cobg0.904
Rv2440cobg0.904
Rv2440cobg0.904
Rv3151nuoG0.904
Rv3151nuoG0.904
Rv0704rplB0.902
Rv0704rplB0.902
Rv0651rplJ0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.984507.181
phosphatePubChem0.9896.9872
adenosine diphosphatePubChem0.979427.201
H(+)PubChem0.9432.01588
deuteriumPubChem0.9312.01588
adenosine monophosphatePubChem0.9347.221
deoxyadenosine triphosphatePubChem0.9491.182
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
magnesiumPubChem0.89924.305
Coomassie bluePubChem0.836695.584
AMPPNPPubChem0.815506.196
glycerolPubChem0.81492.0938
hydron diphosphatePubChem0.796391.981
selenomethioninePubChem0.782196.106
SeMetPubChem0.782196.106
piceatannolPubChem0.731244.243
resveratrolPubChem0.73228.243
quercetinPubChem0.73302.236
azidePubChem0.71442.0201
chloridePubChem0.70735.453