Rv2299c

Tuberculist information
Gene namehtpG
Protein functionProbable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)2570.06
Molecular mass(da)72961.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 647
	  		  	1    MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVD   60
			  	61   TSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASE  120
			  	121  ELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGEGTYTIESVEDAPQGTSVTLH  180
			  	181  LKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE  240
			  	241  TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSH  300
			  	301  APFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDR  360
			  	361  QIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLKEGLLSDIDNRETLLGISSFV  420
			  	421  STYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVD  480
			  	481  EVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKE  540
			  	541  VRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQ  600
			  	601  DRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLAERLARTL

Known structures in the PDB
No Known structures
1 65 129 193 257 321 385 449 513 577 641 Range: 26 to 188  |  Coverage: 25% HATPase_c_3 Range: 234 to 647  |  Coverage: 63% HSP90 Range: 6 to 647  |  Coverage: 99% 1 Range: 245 to 508  |  Coverage: 40% 1 Range: 1 to 232  |  Coverage: 35% 2 Range: 525 to 645  |  Coverage: 18% 3 Range: 26 to 188  |  Coverage: 25% 4
Number of amino acids : 647
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HATPase_c_3PF1358926-188
HSP90PF00183234-647
Mtb Structural Proteome models
Model Number1
Model nameRv2299c
Template2CG9    APDBCREDO
Template coverage4_676
Template Identity(%)39.6
Model coverage(%)99.1
Normalized DOPE score0.401

Structure Models from Chopin
Model Number1
Profiled.14.1.8
Click for model details
zscore50.7
Residue begin245
Residue end508
Model Number2
Profiled.122.1.1 - 3.30.565.10
Click for model details
zscore45
Residue begin1
Residue end232
Model Number3
Profiled.271.1.1
Click for model details
zscore29.41
Residue begin525
Residue end645
Model Number4
Profile3.30.565.10
Click for model details
zscore11.88
Residue begin26
Residue end188
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2299cGene nameConfidence Score
Rv0350dnaK0.995
Rv0384cclpB0.993
Rv0384cclpB0.993
Rv0384cclpB0.993
Rv0384cclpB0.993
Rv3417cgroEL10.978
Rv0440groEL20.976
Rv3418cgroES0.969
Rv3596cclpC10.961
Rv3596cclpC10.961
Rv3596cclpC10.961
Rv3596cclpC10.961
Rv3596cclpC10.961
Rv0351grpE0.941
Rv1308atpA0.938
Rv1308atpA0.938
Rv1308atpA0.938
Rv0352dnaJ10.936
Rv0352dnaJ10.936
Rv0352dnaJ10.936
Rv0563htpX0.933
Rv2373cdnaJ20.929
Rv2373cdnaJ20.929
Rv2373cdnaJ20.929
Rv3610cftsH0.927
Rv3610cftsH0.927
Rv3610cftsH0.927
Rv1437pgk0.92
Rv3846sodA0.906
Rv3846sodA0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
geldanamycinPubChem0.911560.636
radicicolPubChem0.89364.777
magnesiumPubChem0.78724.305
adenosine diphosphatePubChem0.76427.201
17-AAGPubChem0.735585.688
p-iodophenolPubChem0.724220.008
rifabutinPubChem0.712847.005
SeMetPubChem0.706196.106
selenomethioninePubChem0.701196.106